BAFF Expression is Increased in Patients with Lupus Nephritis and Associated with Antinucleosome Antibodies, C1 Inhibitor, Α-1-Acid-Glycoprotein and Endothelial Activation Markers

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“…Several approaches to disease control and prevention were discussed in articles addressing the association of increased B-cell activating factor (BAFF) expression with disease markers in patients with Lupus Nephritis (LN), the potential advantages of retinoids treatment in LN, and the role of glycoprotein M64 (GPM6A) in human thyroid cancer. Eilertsen et al [5] utilized quantitative RT-PCR to analyze gene expression in systemic lupus erythematosus patients and further investigated their reaction with clinical, histological and acute phase protein. They found increased BAFF mRNA expression and concluded that the increase is not reflective of histological disease severity.…”