In recent years, depending on information technology, knowledge and skills, university libraries have established a new "user centered" data service system, which is called personalized information service. Although this service has made some progress in recent years, these systems have only achieved a certain amount of personalized information services. Multi-core processor is the basic process unit of highperformance cloud computing node, which is an important basis to achieve system security, high performance, low power consumption and other high-performance requirements. Cloud computing node, as one of the core components in the high-performance computer system architecture, in addition to the acceleration node, master control unit, communication system, etc., its e ciency has constituted an important basic condition for the realization of the "high e ciency" goal of the system. The emergence of multi-core processors and cloud computing platforms has created conditions for the development of personalized mobile information service platforms in university libraries. Under the technical support of multicore processors and cloud computing platforms, it is also an important goal of mobile libraries in the future to meet the needs of users to search library data information at any time and provide users with diversi ed data services. At present, the knowledge service platform of university library can not only actively select and recommend relevant materials for users according to their knowledge preferences, data utilization habits, and academic backgrounds, but also enable service users to quickly obtain the borrowing expiration prompt, independent consultation and retrieval and other personalized information functions, and carry out more indepth personalized intelligent knowledge consulting services. Based on multi-core processor and cloud computing platform, this paper develops personalized mobile information service platform of university library.