Baicalein: A metabolite with promising antineoplastic activity

Tuli, Hardeep Singh; Aggarwal, Vaishali; Kaur, Jagjit; Aggarwal, Diwakar; Parashar, Gaurav; Parashar, Nidarshana Chaturvedi; Tuorkey, Muobarak J.; Kaur, Ginpreet; Savla, Raj; Sak, Katrin; Kumar, Manoj

doi:10.1016/j.lfs.2020.118183

Cited by 71 publications

(39 citation statements)

References 180 publications

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“…Another compound present in Scutellaria baicalensis , but also in Oroxylum indicum , is baicalein [ 117 , 118 ]. Same as the abovementioned flavonoids, baicalein was found to be active against a variety of cancer cells and thereby acted via different pathways [ 119 ], however, also with limited oral bioavailability [ 120 ]. With regard to MM, baicalein was studied for its effect on U266 cells and showed an IC 50 value of 60 µM after 24 h of incubation [ 121 ].…”

Section: Resultsmentioning

confidence: 99%

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Jöhrer

Ҫiҫek

2021

Cancers

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A literature search on plant natural products with antimyeloma activity until the end of 2020 resulted in 92 compounds with effects on at least one human myeloma cell line. Compounds were divided in different compound classes and both their structure–activity-relationships as well as eventual correlations with the pathways described for Multiple Myeloma were discussed. Each of the major compound classes in this review (alkaloids, phenolics, terpenes) revealed interesting candidates, such as dioncophyllines, a group of naphtylisoquinoline alkaloids, which showed pronounced and selective induction of apoptosis when substituted in position 7 of the isoquinoline moiety. Interestingly, out of the phenolic compound class, two of the most noteworthy constituents belong to the relatively small subclass of xanthones, rendering this group a good starting point for possible further drug development. The class of terpenoids also provides noteworthy constituents, such as the highly oxygenated diterpenoid oridonin, which exhibited antiproliferative effects equal to those of bortezomib on RPMI8226 cells. Moreover, triterpenoids containing a lactone ring and/or quinone-like substructures, e.g., bruceantin, whitaferin A, withanolide F, celastrol, and pristimerin, displayed remarkable activity, with the latter two compounds acting as inhibitors of both NF-κB and proteasome chymotrypsin-like activity.

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Section: Resultsmentioning

confidence: 99%

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Jöhrer

Ҫiҫek

2021

Cancers

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“…Baicalein is a natural flavonoid from the roots of Scutellaria baicalensis and Scutellaria lateriflora , which exhibits antioxidant and anti-inflammatory activities [ 119 ]. Jin et al [ 120 ] found that baicalein inhibited IL-1 β production by NP cells and increased NP ECM synthesis by regulating NF- κ B and MAPK signalling.…”

Section: Natural Pharmacological Productsmentioning

confidence: 99%

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Chen

Zhang

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Intervertebral disc degeneration (IDD) is one of the main causes of low back pain (LBP), which severely reduces the quality of life and imposes a heavy financial burden on the families of affected individuals. Current research suggests that IDD is a complex cell-mediated process. Inflammation, oxidative stress, mitochondrial dysfunction, abnormal mechanical load, telomere shortening, DNA damage, and nutrient deprivation contribute to intervertebral disc cell senescence and changes in matrix metabolism, ultimately causing IDD. Natural products are widespread, structurally diverse, afford unique advantages, and exhibit great potential in terms of IDD treatment. In recent years, increasing numbers of natural ingredients have been shown to inhibit the degeneration of nucleus pulposus cells through various modes of action. Here, we review the pharmacological effects of natural products on nucleus pulposus cells and the mechanisms involved. An improved understanding of how natural products target signalling pathways will aid the development of anti-IDD drugs. This review focuses on potential IDD drugs.

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“…Baicalein (Bai), Table 3, is produced by the root of Chinese skullcap, Scutellaria baicalensis Georgi (Lamiaceae), and it is a bioactive substance part of traditional Chinese medicine. Bai has several beneficial effects conferred through its anti-oxidant, anti-viral, anti-inflammatory, anti-angiogenic, and anti-cancer activities [157]. Moreover, studies have shown that Bas exerts a neuroprotective role in AD [158].…”

Section: Flavonoidsmentioning

confidence: 99%

Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease

et al. 2021

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Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer’s disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, have been implicated in AD. In particular, MMP-2 and MMP-9 are able to trigger several neuroinflammatory and neurodegenerative pathways. In this review, we summarize and discuss existing literature on natural marine and terrestrial compounds, as well as their ability to modulate MMP-2 and MMP-9, and we evaluate their potential as therapeutic compounds for neurodegenerative and neuroinflammatory diseases, with a focus on Alzheimer’s disease.

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Baicalein: A metabolite with promising antineoplastic activity

Cited by 71 publications

References 180 publications

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease

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