Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro

Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers

“…Baicalein (Fig. 1a) is a flavonoid isolated from baikal skullcap and has been shown to have neuroprotective effects in various in vitro and in vivo PD models [12][13][14]. Those results suggest that baicalein may be a novel neuroprotective agent with multiple targets for the treatment of PD.…”

Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism

“…Following 6-OHDA injection, some behavioral, biochemical, and pathological hallmarks of PD develop (Schober, 2004). The toxic effects of 6-OHDA are attributed to enhanced oxidative stress burden, inflammatory processes and apoptosis (Mu et al, 2009). Mitochondrial dysfunction and increased oxidative stress are also responsible for neuronal loss in patients with PD (Henchcliffe and Beal, 2008).…”

Effect of total flavonoids from Scutellaria baicalensis on dopaminergic neurons in the substantia nigra

“…Its dry root, Radix Scutellariae, has been demonstrated to exert free radical scavenging and antioxidant activities, which can be used to treat various types of chronic illness, such as inflammation, allergies, respiratory and cardiovascular disease, and fever (4-6), Baicalein, a flavonoid obtained from Radix Scutellariae provides neuroprotective effects for 6-hydroxydopamine-induced animal models of PD (7,8). Baicalein has also been shown to protect against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria (9), and to attenuate inflammation-mediated degeneration of dopaminergic neurons (10).…”