Baicalein Protects Rats with Diabetic Cardiomyopathy Against Oxidative Stress and Inflammation Injury via Phosphatidylinositol 3-Kinase (PI3K)/AKT Pathway

Ma, Lin; Li, Xiang Peng; Ji, Heng; Liu, Yue Fen; Li, En Ze

doi:10.12659/msm.911455

Cited by 38 publications

(23 citation statements)

References 21 publications

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“…Another study reported that BL exhibited prominent ameliorative effects against oxidative and inflammatory injury of myocardial tissues in diabetic animals, which was mediated by PI3K/Akt signaling cascade [28]. In addition, the hepatoprotective efficacy of BL was demonstrated in rodents with diabetic live injury [17].…”

Section: Discussionmentioning

confidence: 99%

Baicalein Neutralizes Hypercholesterolemia-Induced Aggravation of Oxidative Injury in Rats

Alsaad¹,

Mohany²,

Almalki³

et al. 2020

Int. J. Med. Sci.

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Hypercholesterolemia is a major risk factor for several cardiovascular and metabolic diseases as it triggers oxidative and pro-inflammatory cascades. Baicalein (BL) is a natural flavone with multiple therapeutic properties. The present study aimed to evaluate the potential protective effect of BL supplementation in hypercholesterolaemic rats. Rats were fed a high-cholesterol diet (HCD) for six weeks and then orally administered BL at two doses (25 and 50 mg/kg body weight/day) for four weeks. Serum lipids, liver enzymes, cardiac enzymes, renal markers, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-10 (IL-10), caspase-3, nitric oxide (NO) and prostaglandin-2 (PGE-2) were measured. In renal, hepatic, and cardiac tissues, thiobarbituric acid-reactive (TBARS) substance, glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were measured. The altered levels of lipoproteins, aminotransferases, creatine kinases, and urea in hypercholesterolemic animals were significantly corrected by BL. Inflammatory and apoptotic biomarkers were also markedly attenuated in the HCD group following BL treatment. Hypercholesterolemia considerably induced the lipid peroxidation product, TBARS, and oxidative radicals in cardiac, hepatic, and renal tissues, which were attenuated by BL treatment, particularly, at the 50 mg/kg/day dose. BL enhanced the activities of superoxide dismutase, catalase, and glutathione peroxidase that were suppressed by HCD. Histological alterations induced by cholesterol overload in cardiac, hepatic, and renal tissues were ameliorated by BL supplementation. Our results show that the BL treatments (25 and 50 mg/kg/day) to HCD fed rats improved all the altered parameters. These results demonstrate that BL treatment improves cardiac, renal and hepatic dysfunctions in hypercholesterolaemic rats by activation of cellular antioxidant enzymes and/or suppression of inflammatory cytokines.

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Section: Discussionmentioning

confidence: 99%

Baicalein Neutralizes Hypercholesterolemia-Induced Aggravation of Oxidative Injury in Rats

Alsaad¹,

Mohany²,

Almalki³

et al. 2020

Int. J. Med. Sci.

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show abstract

“…The treatment of baicalein in HepG2 cells (0.001 umol/L and 0.01 umol/L) enhanced glucose uptake and glycolysis and suppressed [188]. In addition, baicalein prevents oxidative stress and inflammation in diabetic cardiomyopathy rats through the regulation of PI3K/AKT signaling [189]. Baicalein alleviates hepatic inflammation in diabetic db/db mice via the modulation of HMGB1/TLR4/NF-κB signaling [190].…”

Section: Anti-diabetic Effects Of Selected Flavonoidsmentioning

confidence: 99%

Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels

et al. 2019

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Diabetes mellitus (DM) is a prevailing global health metabolic disorder, with an alarming incidence rate and a huge burden on health care providers. DM is characterized by the elevation of blood glucose due either to a defect in insulin synthesis, secretion, binding to receptor, or an increase of insulin resistance. The internal and external factors such as obesity, urbanizations, and genetic mutations could increase the risk of developing DM. Flavonoids are phenolic compounds existing as secondary metabolites in fruits and vegetables as well as fungi. Their structure consists of 15 carbon skeletons and two aromatic rings (A and B) connected by three carbon chains. Flavonoids are furtherly classified into 6 subclasses: flavonols, flavones, flavanones, isoflavones, flavanols, and anthocyanidins. Naturally occurring flavonoids possess anti-diabetic effects. As in vitro and animal model’s studies demonstrate, they have the ability to prevent diabetes and its complications. The aim of this review is to summarize the current knowledge addressing the antidiabetic effects of dietary flavonoids and their underlying molecular mechanisms on selected pathways: Glucose transporter, hepatic enzymes, tyrosine kinase inhibitor, AMPK, PPAR, and NF-κB. Flavonoids improve the pathogenesis of diabetes and its complications through the regulation of glucose metabolism, hepatic enzymes activities, and a lipid profile. Most studies illustrate a positive role of specific dietary flavonoids on diabetes, but the mechanisms of action and the side effects need more clarification. Overall, more research is needed to provide a better understanding of the mechanisms of diabetes treatment using flavonoids.

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“…Another study reported that BL exhibited prominent ameliorative effects against oxidative and inflammatory injury of myocardial tissues in diabetic animals, which was mediated by PI3K/Akt signaling cascade (24). In addition, the hepatoprotective efficacy of BL was demonstrated in rodents with diabetic live injury (13).…”

Section: Discussionmentioning

confidence: 99%

Baicalein neutralizes hypercholesterolemia-induced aggravation of oxidative injury in rats

Alsaad

Almalki

Almutham

et al. 2019

Preprint

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Background: Hypercholesterolemia is a major risk factor for several cardiovascular and metabolic diseases through triggering oxidative and pro-inflammatory cascades. Baicalein (BL) is a natural flavone with multiple therapeutic properties. Thus, the present study aims to highlight the protective value associated with BL supplementation in hypercholesterolemic rats. Keywords : hypercholesterolemia, baicalein, inflammation, oxidative stress Methods: In this context, animals were fed for sex weeks on high cholesterol diet (HCD) then BL oral treatments in two doses (25 and 50 mg/kg/day) was started and continued for four weeks. In serum, lipid profile, liver enzymes, cardiac enzymes, renal markers, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-10 (IL10), caspase-3, nitric oxide (NO) and prostaglandin-2 (PG-2) levels were estimated. In renal, hepatic and cardiac cells, thiobarbituric acid-reactive substance (TBARS), glutathione (GSH), Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were measured. Results: In hypercholesterolemic animals, the altered levels of lipoproteins, aminotransferases, creatine kinases and urea were significantly corrected by BL. Inflammatory and apoptosis biomarkers were also markedly attenuated in HCD groups following BL treatment. Hypercholesterolemia considerably evoked the lipid peroxidation product, TBARS, and oxidative radicals in cardiac, hepatic and renal tissues, which were attenuated by BL treatment, particularly the 50 mg/kg/day dose. BL improved the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) following their suppression in HCD groups. In addition, the histological alterations induced by cholesterol overload in the cardiac, hepatic and renal tissues were ameliorated by BL supplementation. Conclusions: As a conclusion, the up-regulated oxidative damage, inflammation and necrosis observed within the hypercholesterolemic animals could be enhanced by co-administration BL. Activation of the cellular antioxidant enzymes alone with suppression of inflammatory cytokines may be involved to mediate these prominent effects.

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Baicalein Protects Rats with Diabetic Cardiomyopathy Against Oxidative Stress and Inflammation Injury via Phosphatidylinositol 3-Kinase (PI3K)/AKT Pathway

Cited by 38 publications

References 21 publications

Baicalein Neutralizes Hypercholesterolemia-Induced Aggravation of Oxidative Injury in Rats

Baicalein Neutralizes Hypercholesterolemia-Induced Aggravation of Oxidative Injury in Rats

Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels

Baicalein neutralizes hypercholesterolemia-induced aggravation of oxidative injury in rats

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