Baicalin ameliorates neuropathic pain by suppressing HDAC1 expression in the spinal cord of spinal nerve ligation rats

Abstract

The present findings suggest that baicalin can ameliorate neuropathic pain by suppressing HDAC1 expression and preventing histone-H3 acetylation in the spinal cord dorsal horn of SNL rats.

Repeated forced swim stress prior to complete Freund’s adjuvant injection enhances mechanical hyperalgesia and attenuates the expression of pCREB and ΔFosB and the acetylation of histone H3 in the insular cortex of rat

“…Systemic administration of HDAC inhibitor has also analgesic effect in formalin-evoked acute inflammation via expression changes of the metabotropic glutamate receptor (mGluR)2 in the dorsal root ganglion (DRG) and spinal cord (Chiechio et al, 2009). Peripheral nerve injury decreases histone acetylation and increases HDAC in the spinal cord (Cherng et al, 2014). Intrathecal administration of HDAC inhibitor has analgesic effect in peripheral nerve injury (Denk et al, 2013).…”

Is there any therapeutic value for the use of histone deacetylase inhibitors for chronic pain?

“…The interactions between HATs and HDACs determine the net balance of histone acetylation (Binder et al, 2013). Mounting evidence suggests that during pain-related synaptic plasticity, the expression and activities of HDACs are dynamic (Geranton and Tochiki, 2015;Cherng et al, 2014;Matsushita et al, 2013;Kiguchi et al, 2013;Denk et al, 2013). Therefore, in the present review, we focus on mechanisms of histone acetylation and the role of HDACs in chronic pain and discuss recent attempts to treat chronic pain with HDAC inhibitors (HDACIs).…”

“…For example, it has been reported that in a rat model of spinal nerve ligation (SNL), HDAC1 expression in the nuclear fraction of the ipsilateral lumbar spinal dorsal horn was significantly increased, while acetyl-H3 was decreased from post-surgical day 1-7 (Cherng et al, 2014). However, in a spared nerve injury (SNI) model, the expression of HDAC1 was unchanged, whereas the expression levels of HDAC2 and 5 were decreased in the spinal dorsal horn 7 d after surgery (Shen et al, 2014).…”

“…In addition to HDAC expression, other studies have focused on the global acetylation levels in animal models of chronic pain. For example, it has been observed that SNL significantly reduced H3 acetylation in the spinal cord dorsal horn (Cherng et al, 2014). However, in the CCI-induced neuropathic pain model, the acetyl-H3K9 levels were increased (Yin et al, 2013;Shao et al, 2014).…”

Epigenetic regulation of persistent pain

“…Interestingly, two laboratories showed that class I HDAC, mainly HDAC1 , is important for neuropathic pain while Class II in important for inflammatory pain [147, 166–167]. …”