Baicalin attenuate diet-induced metabolic syndrome by improving abnormal metabolism and gut microbiota

Lin, Yang; Wang, Ziyuan; Wang, Ma-Jie; Jiang, Zheng‐Meng; Qin, Ya-Qiu; Huang, Tianqing; Song, Yu; Liang, Hui-Ting; Liu, E‐Hu

doi:10.1016/j.ejphar.2022.174996

Cited by 10 publications

(7 citation statements)

References 40 publications

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“…It is broadly acknowledged that flavonoid compounds can modulate intestinal bacteria [ 44 , 45 , 47 , 90 ]. Specifically, baicalin, a plant-derived flavonoid, has a variety of biological activities, which inhibits lung injury by manipulating the production of intestinal bacteria and short-chain fatty acids [ 91 ], improves metabolic abnormalities and intestinal bacteria, and reduces diet-induced metabolic syndrome [ 92 ]. Interestingly, total flavonoids of Abelmoschus manihot effectively ameliorate the ulcerative colitis aggravated by chronic stress and improve depressive-like phenotype, disturbed intestinal flora, and intestinal barrier function in chronic stress mice [ 93 ].…”

Section: Discussionmentioning

confidence: 99%

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Cao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Okra, possessing various bioactive components, is used to treat different diseases. This study sought to estimate the intervention effects of okra extract (OE) on brain-gut peptides (BGPs) and intestinal microorganisms in sleep deprivation (SD) rats. Methods. SD rat models were established using the modified multiple platform method and then treated with normal saline, diazepam tablets, or different doses of OE. Body weight and average daily water consumption of rats were recorded. Depressive behaviors of rats were assessed by the open field test and sucrose preference test. Serum levels of noradrenaline, melatonin, inflammatory factors (IL-1β/IL-6/TNF-α/IL-4/IL-10), and BGP indexes, including gastrin (GAS), motilin (MTL), 5-hydroxytryptamine (5-HT), cholecystokinin (CCK), and vasoactive intestinal peptide (VIP) were measured by ELISA. Additionally, the DNA relative contents of representative intestinal microorganisms in the collected rat feces were determined using RT-qPCR. Results. SD decreased body weight and average daily water consumption and induced depressive behaviors as well as stress and inflammatory responses in rats. SD rats exhibited lowered GAS, MTL, 5-HT, and VIP but elevated CCK and showed diminished DNA relative contents of Bacteroidetes and probiotics (Bifidobacteria and Lactobacilli) but increased Clostridium perfringens. OE at different doses ameliorated the depressive behaviors and mitigated the stress and inflammatory responses in SD rats, raised the serum contents of GAS, MTL, 5-HT, and VIP, reduced CCK level, elevated the DNA relative contents of Bacteroidetes and probiotics, but diminished Clostridium perfringens. OE exhibited similar intervention effects to diazepam tablets (positive control). Conclusion. OE exerts intervention effects on BGPs and intestinal microorganisms in SD rats.

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Section: Discussionmentioning

confidence: 99%

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Cao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Some scholars have found that baicalin rebalances the gut microbial composition pattern impaired by ionizing radiation (IR) and alleviates IR-induced apoptosis of the gut microbiota ( Wang et al., 2020b ). In addition, other scholars have also done research on baicalin; they found that baicalin can improve abnormal metabolism and gut microbiota in high-fat diet (HFD)-induced metabolic syndrome (MetS) in mice ( Lin et al., 2022 ). Glycosides and flavonoids from P. thomsonii leaves (PL) alleviated type 2 diabetes in high-fat diet plus streptozotocin-induced mice.…”

Section: Traditional Chinese Medicines and Gmmentioning

confidence: 99%

The traditional Chinese medicine and non-small cell lung cancer: from a gut microbiome perspective

Wang

Hou

Meng

et al. 2023

Front. Cell. Infect. Microbiol.

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Non-small cell lung cancer (NSCLC) is one of the most serious diseases affecting human health today, and current research is focusing on gut flora. There is a correlation between intestinal flora imbalance and lung cancer, but the specific mechanism is not clear. Based on the “lung and large intestine being interior-exteriorly related” and the “lung-intestinal axis” theory. Here, based on the theoretical comparisons of Chinese and western medicine, we summarized the regulation of intestinal flora in NSCLC by active ingredients of traditional Chinese medicine and Chinese herbal compounds and their intervention effects, which is conducive to providing new strategies and ideas for clinical prevention and treatment of NSCLC.

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“…Биоактивные флавоноиды, выделенные из корня Scutellaria baicalensis Georgi, помимо влияния на снижение массы тела и резистентности к инсулину, риска формирования сахарного диабета 2 типа [28], влияют на состав микробиоты кишечника. Флавоноиды (например, антоцианы) не могут полностью всасываться в желудочно-кишечном тракте и метаболизируются микробиотой кишечника [29,30]. Употребление лютеолина, противовоспалительного флавоноида, оказывает смягчающее действие на воспаление жировой ткани и резистентность к инсулину, этот эффект может быть частично опосредован путем подавления активности M1-макрофагов в жировой ткани [31].…”

Section: питание и метаболический синдромunclassified

Nutrition and the state of the intestinal microflora in the formation of the metabolic syndrome

Patrakeeva

Shtaborov

2022

Obes. metabol.

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The literature review presents the results of modern studies of the relationship between diet and intestinal microbiota in the regulation of metabolic disorders. Metabolic syndrome, which is a symptom complex that combines abdominal obesity, insulin resistance, hyperglycemia, dyslipidemia and arterial hypertension, remains an important problem, being a risk factor for cardiovascular, neurodegenerative, oncological diseases and the development of type 2 diabetes mellitus. Although the pathogenesis of the metabolic syndrome has not yet been fully elucidated, it is known that visceral obesity and its associated complications, such as dyslipidemia and increased levels of pro-inflammatory cytokines, play a central role. The article presents data on the impact of the consumption of certain food products, the inclusion of plant biologically active substances (flavonoids, polyphenols, etc.) in the diet, as well as the use of elimination diets with the exclusion of carbohydrates or fats from the diet, on reducing the risk of cardiovascular accidents, levels of fasting glucose, total cholesterol, LDL, triglycerides, C-reactive protein, leptin, insulin, reduction in body weight and waist circumference, reduction in the level of circulating endotoxins and changes in the activity of immunocompetent cells. Data are presented on the possible influence of the intestinal microbiota in maintaining inflammation and the formation of degenerative changes in the body. The role of changes in the ratio of the levels of pathogenic microflora, bifidobacteria and lactobacilli in the formation of a pathological condition is shown.

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Baicalin attenuate diet-induced metabolic syndrome by improving abnormal metabolism and gut microbiota

Cited by 10 publications

References 40 publications

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

The traditional Chinese medicine and non-small cell lung cancer: from a gut microbiome perspective

Nutrition and the state of the intestinal microflora in the formation of the metabolic syndrome

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