Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response

Wu, Shuai-Cheng; Chu, Xiuling; Su, Jianqing; Cui, Zhen-Qiang; Zhang, Liyan; Yu, Zilin; Wu, Zong-Mei; Cai, Meng-Lu; Li, Hanxiao; Zhang, Zi-Jie

doi:10.1016/j.phymed.2018.04.063

Cited by 41 publications

(22 citation statements)

References 35 publications

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“…Previous studies evidenced that supplemental PE based on baicalin or chlorogenic acid was associated with an improvement in growth performance of animals (Chen et al, 2018a; Wu S.C. et al, 2018). Similarly, the current study revealed a mitigation of S. pullorum -induced impairment of production performance of laying hens in the presence of PE, indicated by the increased egg production and ADFI as well as feed efficiency.…”

Section: Discussionmentioning

confidence: 97%

“…The extracts from Flos lonicerae and Baikal skullcap were associated with various biological properties such as heat-clearing, antioxidation and immune-regulation (Mo et al, 2012). The principal active components of Flos lonicerae and Baikal skullcap are respectively characterized as chlorogenic acid and baicalin (Kaplya et al, 2004), which were associated with antibacterial and anti-inflammation properties in vitro (Lou et al, 2011; Palocz et al, 2016; Fu et al, 2018; Wu S.C. et al, 2018). It was also reported that chlorogenic acid or baicalin addition modulated immune responses and improved intestinal homeostasis in pigs and mice (Chen et al, 2018b; Wu S.C. et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…The principal active components of Flos lonicerae and Baikal skullcap are respectively characterized as chlorogenic acid and baicalin (Kaplya et al, 2004), which were associated with antibacterial and anti-inflammation properties in vitro (Lou et al, 2011; Palocz et al, 2016; Fu et al, 2018; Wu S.C. et al, 2018). It was also reported that chlorogenic acid or baicalin addition modulated immune responses and improved intestinal homeostasis in pigs and mice (Chen et al, 2018b; Wu S.C. et al, 2018). A combination of the supplementation of chlorogenic acid and geniposide (a kind of glycoside that similar to baicalin in structure) was demonstrated to mitigate high-fat diet-induced intestinal inflammation and barrier dysfunction in mice (Peng et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Supplemental Plant Extracts From Flos lonicerae in Combination With Baikal skullcap Attenuate Intestinal Disruption and Modulate Gut Microbiota in Laying Hens Challenged by Salmonella pullorum

et al. 2019

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Dietary inclusions of baicalin and chlorogenic acid were beneficial for intestinal health in pigs. Nevertheless, it is unknown whether these plant-derived products had protection for intestine against bacterial challenge in chickens. This study was aimed at evaluating the potential mitigating effects of plant extracts (PE) from Flos lonicerae combined with Baikal skullcap (the active components are chlorogenic acid and baicalin) on intestinal disruption and dysbacteriosis induced by Salmonella pullorum in laying hens. A total of 216 41-week-old layers were randomly divided into 3 groups (6 replicates per group): negative control (NC), S. pullorum -infected positive control (PC), and the S. pullorum -infected group with supplementation of PE at 1000 mg/kg. All birds except those in NC were challenged with S. pullorum at the end of 4 weeks of the experiment. S. pullorum challenge impaired ( P < 0.05) the production performance (egg production, feed intake, and feed efficiency) of laying hens, increased ( P < 0.05) serum endotoxin content and frequency of Salmonella -positive organs, as well as up-regulated ( P < 0.05) ileal expression of pro-inflammatory cytokines including IFNG , TNFA , IL8 , and IL1B , whereas PE addition reversed ( P < 0.05) these changes and increased ( P < 0.05) ileal IL10 expression. Supplemental PE moderated ileal microbiota dysbiosis in challenged birds, characterized by a reduced abundance of Firmicutes along with increased abundances of Bacteroidetes ( Bacteroides ), Deferribacteres and several butyrate-producers such as Prevotellaceae , Faecalibacterium , Blautia , Butyricicoccus, Lachnoclostridium , and Olsenella , which may assist with energy harvesting and boost anti-inflammatory capacity of host. The decreased abundance of Firmicutes with the increased abundance of Bacteroidetes caused by PE addition had positive correlations with the decreased expression of ileal pro-inflammatory cytokines. The increased abundances of Bacteroidetes ( Bacteroides ) and Prevotellaceae following PE addition were also positively correlated with the improvement of performance (egg production and feed intake) of laying hens. Collectively, supplemental PE from Flos lonicerae in combination with Baikal skullcap alleviated ...

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Supplemental Plant Extracts From Flos lonicerae in Combination With Baikal skullcap Attenuate Intestinal Disruption and Modulate Gut Microbiota in Laying Hens Challenged by Salmonella pullorum

et al. 2019

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“…Baicalin also improved the health of mice and prevented their infection with Helicobacter pylori in a model of inflammation by interfering with the growth and virulence of H. pylori [ 16 ]. Baicalin protected mice against S. Typhimurium challenge by modulating both the bacterium’s virulence and the host’s immune response [ 17 ]. In our previous work, we found that baicalin could suppress the NF-κB and NLRP3 inflammasome signalling pathways induced by G. parasuis in porcine aortic vascular endothelial cells (PAVECs) [ 18 ] and piglet mononuclear phagocytes (PMNPs) [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of baicalin on piglets challenged with Glaesserella parasuis

Yin

Zuo

et al. 2020

Vet Res

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Glaesserella parasuis ( G. parasuis ) causes porcine vascular inflammation and damage. Baicalin is reported to have antioxidant and anti-inflammatory functions. However, whether baicalin protects piglets against G. parasuis challenge and the potential protective mechanism have not been investigated. Therefore, in this study, we comprehensively examined the protective efficacy of baicalin in piglets challenged with G. parasuis and the possible protective mechanism. Our results show that baicalin attenuated the release of the inflammation-related cytokines interleukin (IL) 1β, IL6, IL8, IL10, and tumour necrosis factor α (TNF-α) and reduced high mobility group box 1 (HMGB1) production and cell apoptosis in piglets infected with G. parasuis . Baicalin also inhibited the activation of the mitogen-activated protein kinase (MAPK) signalling pathway and protected piglets against G. parasuis challenge. Taken together, our data suggest that baicalin could protect piglets from G. parasuis by reducing HMGB1 release, attenuating cell apoptosis, and inhibiting MAPK signalling activation, thereby alleviating the inflammatory response induced by the bacteria. Our results suggest that baicalin has utility as a novel therapeutic drug to control G. parasuis infection.

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“…Baicalin has been shown exhibiting important biological functions. Baicalin could provide protection against Salmonella typhimurium infection, reduce the bacterial virulence, and modulate host response [9]. Baicalin significantly attenuated the production of HMGB1 in peripheral blood monocytes induced by Haemophilus parasuis during inflammation process [10].…”

Section: Introductionmentioning

confidence: 99%

Effect of Baicalin-Aluminum Complexes on Fecal Microbiome in Piglets

Zhuang

Li-wei

et al. 2019

IJMS

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The gut microbiome has important effects on gastrointestinal diseases. Diarrhea attenuation functions of baicalin (BA) is not clear. Baicalin–aluminum complexes (BBA) were synthesized from BA, but the BBA’s efficacy on the diarrhea of piglets and the gut microbiomes have not been explored and the mechanism remains unclear. This study has explored whether BBA could modulate the composition of the gut microbiomes of piglets during diarrhea. The results showed that the diarrhea rate reduced significantly after treatment with BBA. BBA altered the overall structure of the gut microbiomes. In addition, the Gene Ontology (GO) enrichment analysis indicated that the functional differentially expressed genes, which were involved in the top 30 GO enrichments, were associated with hydrogenase (acceptor) activity, nicotinamide-nucleotide adenylyltransferase activity, and isocitrate lyase activity, belong to the molecular function. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that flagellar assembly, bacterial chemotaxis, lipopolysaccharide biosynthesis, ATP-binding cassette transporters (ABC) transporters, biosynthesis of amino acids, and phosphotransferase system (PTS) were the most enriched during BBA treatment process. Taken together, our results first demonstrated that BBA treatment could modulate the gut microbiomes composition of piglets with diarrhea, which may provide new potential insights on the mechanisms of gut microbiomes associated underlying the antimicrobial efficacy of BBA.

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Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response

Cited by 41 publications

References 35 publications

Supplemental Plant Extracts From Flos lonicerae in Combination With Baikal skullcap Attenuate Intestinal Disruption and Modulate Gut Microbiota in Laying Hens Challenged by Salmonella pullorum

Supplemental Plant Extracts From Flos lonicerae in Combination With Baikal skullcap Attenuate Intestinal Disruption and Modulate Gut Microbiota in Laying Hens Challenged by Salmonella pullorum

The effects of baicalin on piglets challenged with Glaesserella parasuis

Effect of Baicalin-Aluminum Complexes on Fecal Microbiome in Piglets

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