Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats

Ding, Li-Li-Qiang; Jia, Chenglin; Zhang, Yong; Wang, Wenjian; Zhu, Weiliang; Chen, Yu; Zhang, Teng

doi:10.1016/j.biopha.2018.12.086

Cited by 44 publications

(35 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Justicidin D exhibits anti-inflammatory properties 24 , Licoricidin is an antimetastatic molecule 25 whereas euphol is used against asthma and cancer along with syphilis, and rheumatism 26 . Schisandrene has anti-oxidant activity 27 , curine is reported as a vasodilator 27 , angoluvarin has antimicrobial activity 28 , baicalin is used to treat cardiovascular diseases, inflammation and hypertension 29 . Glycyrrhetic acid shows anti-inflammatory, anti-ulcer, hepatoprotective, anti-allergic, anti-tumor, antioxidant and anti-diabetic activity 30 .…”

Section: Discussionmentioning

confidence: 99%

Coronavirus disease 2019 drug discovery through molecular docking

Singh

Flórez

2020

F1000Res

View full text Add to dashboard Cite

Background: The dawn of the year 2020 witnessed the spread of the highly infectious and communicable disease coronavirus disease 2019 (COVID-19) globally since it was ﬁrst reported in 2019. Severe acute respiratory syndrome coronavirus-2 is the main causative agent. In total, 3,096,626 cases and 217,896 deaths owing to COVID-19 were reported by 30th April, 2020 by the World Health Organization. This means infection and deaths show an exponential growth globally. In order to tackle this pandemic, it is necessary to ﬁnd possible easily accessible therapeutic agents till an effective vaccine is developed. Methods: In this study, we present the results of molecular docking processes through high throughput virtual screening to analyze drugs recommended for the treatment of COVID-19. Results: Atovaquone, fexofenadine acetate (Allegra), ethamidindole, baicalin, glycyrrhetic acid, justicidin D, euphol, and curine are few of the lead molecules found after docking 129 known antivirals, antimalarial, antiparasitic drugs and 992 natural products. Conclusions: These molecules could act as an effective inhibitory drug against COVID-19.

show abstract

Section: Discussionmentioning

confidence: 99%

Coronavirus disease 2019 drug discovery through molecular docking

Singh

Flórez

2020

F1000Res

View full text Add to dashboard Cite

show abstract

“…Baicalin is a major flavone component found in Scutellaria baicalensis Georgi, a medicinal herb with a long history of clinical application in the treatment of a host of diseases primarily including intestinal disorders and hypertension (Zhao et al, 2016). Anti-inflammatory and anti-hypertensive activities of baicalin have been previously documented (Zhao et al, 2016; Ding et al, 2019). However, whether baicalin is pharmacologically active at preserving the intestinal barrier integrity under hypertensive conditions remains to be investigated.…”

Section: Introductionmentioning

confidence: 94%

Baicalin Protects Against Hypertension-Associated Intestinal Barrier Impairment in Part Through Enhanced Microbial Production of Short-Chain Fatty Acids

Ding

Tang

et al. 2019

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Impaired intestinal barrier plays an important role in the pathogenesis of hypertension primarily through promoting the development of chronic low-grade inflammation. Baicalin is the major flavonoid component of Scutellaria baicalensis Georgi, a medicinal plant commonly used for the treatment of inflammatory intestinal disorders and hypertension in traditional Chinese medicine. However, it remains to be elucidated whether baicalin alleviates hypertension-associated intestinal barrier impairment. The current study thus investigated the effects of baicalin on the intestinal barrier integrity, the intestinal expression of genes encoding proinflammatory factors and tight junction proteins, the serum levels of the inflammatory markers, the amount of fecal short-chain fatty acids (SCFAs) and the abundance of SCFAs-producing bacteria in the spontaneously hypertensive rats (SHRs). The results showed that baicalin alleviated the pathological lesions in the ilium and the proximal colon in the SHRs. Baicalin treatment resulted in decreased ileal and colonic expression of proinflammatory genes in the SHRs. In addition, baicalin treatment attenuated hypertension-associated intestinal hyperpermeability and decreased the serum levels of inflammatory indicators such as high-sensitivity C-reactive protein (hs-CRP), interleukin 1 beta, and IL-6 in the SHRs. The protective effect of baicalin on the intestinal integrity was also supported by well-preserved intestinal ultrastructure and increased intestinal expression of genes encoding tight junction proteins such as zonula occludens-1 (ZO-1), cingulin, and occludin in the SHRs. Lastly, baicalin treatment increased the amount of fecal SCFAs and the abundance of SCFAs-producing bacteria in the SHRs. In conclusion, the work here provides for the first time the morphological, biochemical, and molecular evidence supporting the protective effects of baicalin on the intestinal integrity in the SHRs, which may help better understand the therapeutic effects of S. baicalensis Georgi in the treatment of hypertension.

show abstract

“…Cumulative findings support the notion that inflammation, oxidative stress and endothelial dysfunction leads to the development of hypertension (Dinh et al, 2014). Targeting these pathogenesis processes is indicated to be a critical mechanisms underlying the baicalin hypotensive effect and subsequent cardiovascular events (Ding et al, 2019).…”

Section: Hypertensionmentioning

confidence: 65%

“…Another potential mechanism involved in the hypertensionprotecting effects of baicalin is enhancing endothelial nitric oxide synthase (eNOS) -induced production of endogenous NO in HUVECs (Chen et al, 2013). Apart from the above pathogenetic mechanisms involving baicalin, baicalin lowered blood pressure partially by relaxing vascular smooth muscle by decreasing Ca 2+ levels and the enhancing K ATP function in VSMCs (Ding et al, 2019). The combined application of baicalin and berberine was also found to relax blood vessels, owing to the voltage-dependent Ca 2+ channel (VDCC) (Wu et al, 2020).…”

Section: Hypertensionmentioning

confidence: 99%

Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review

et al. 2020

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) is the leading cause of high morbidity and mortality worldwide, which emphasizes the urgent necessity to develop new pharmacotherapies. In eastern countries, traditional Chinese medicine Scutellaria baicalensis Georgi has been used clinically for thousands of years. Baicalin is one of the main active ingredients extracted from Chinese herbal medicine S. baicalensis. Emerging evidence has established that baicalin improves chronic inflammation, immune imbalance, disturbances in lipid metabolism, apoptosis and oxidative stress. Thereby it offers beneficial roles against the initiation and progression of CVDs such as atherosclerosis, hypertension, myocardial infarction and reperfusion, and heart failure. In this review, we summarize the pharmacological features and relevant mechanisms by which baicalin regulates CVDs in the hope to reveal its application for CVDs prevention and/or therapy.

show abstract

Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats

Cited by 44 publications

References 21 publications

Coronavirus disease 2019 drug discovery through molecular docking

Coronavirus disease 2019 drug discovery through molecular docking

Baicalin Protects Against Hypertension-Associated Intestinal Barrier Impairment in Part Through Enhanced Microbial Production of Short-Chain Fatty Acids

Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review

Contact Info

Product

Resources

About