Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation

Zhu, Jianping; Wu, Haiming; Ye, Zi; Xia, Xuewei; Xie, Meng-zhou; Yuan, Zhiying

doi:10.1155/2021/5554363

Cited by 8 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kaixinsan alleviated depressive symptoms by modulating the gut-brain axis, improving the intestinal microenvironment and inhibiting neuroin ammation and activation of the HPA axis in the brain of CUMS model mice [53]. Baihe Jizihuang Decoction attenuated CUMS-induced depression-like behavior by regulating BDNF and intestinal ora disorder through the [54]gut-brain axis. In addition, Yu et al found that paeoni orin can be converted into benzoic acid by the intestinal ora and enter the brain through the blood-brain barrier, where it exerts an antidepressant effect [55].…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and Visual Analysis of Research on the Links between the Microbiome-Gut-Brain axis and Depression

Peng

Luo

et al. 2022

Preprint

View full text Add to dashboard Cite

Background The pathways and mechanisms underlying the associations between the gut microbiome and the brain are collectively known as the microbiome-gut-brain axis (MGBA). Depression is a common and frequent psychological and psychiatric disease. The interactions comprising the MGBA may play a role in the pathogenesis of depression. Nevertheless, the general aspects of the links between the MGBA and depression have not been systematically investigated through bibliometric analysis. Methods Publications from 1994 to 2022, focusing on the links between the MGBA and depression, were downloaded from the Web of Science Core Collection. HistCite, VOSviewer, CiteSpace, and the Bibliometrix Package and were used for bibliometric analysis and visualization. The main analyses we performed included collaboration network analysis, co-citation analysis, co-occurrence analysis, and citation burst detection. Results A total of 829 publications related to the relationship between the MGBA and depression were identified. The number of such publications has been rapidly growing since 2014. The People's Republic of China, University College Cork, and John F. Cryan were the most influential country, institute, and scholar, respectively. BRAIN BEHAV IMMUN and NUTRIENTS were the most productive and co-cited journals. Five hot topics in research linking the MGBA with depression were depression, gut microbiota, gut-brain axis, microbiota, and anxiety. Five frontier topics in the field were cytokine, maternal separation, neuroinflammation, probiotics, and vagus. The most representative and symbolic reference with the highest co-citation number was an article by Bravo J. A. et al. (2011). Conclusions These results provide an instructive perspective for research on the relationship between the MGBA and depression, and a timely review and analysis of research hotspots and research trends, which will promote the development of this field. Future research will focus on understanding the underlying mechanism of action of the MGBA on depression, and on elucidating microbial-based interventions and treatment strategies for depression.

show abstract

Section: Discussionmentioning

confidence: 99%

Bibliometric and Visual Analysis of Research on the Links between the Microbiome-Gut-Brain axis and Depression

Peng

Luo

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Microbiome‐gut‐brain axis as a novel hotspot in depression

Ma,

Xu,

Bai

et al. 2024

Brain-X

View full text Add to dashboard Cite

As a prevalent psychiatric disorder, the etiology of depression remains largely elusive, necessitating further investigation into its pathophysiological underpinnings. Notably, the comorbidity of depression with other mental health conditions and chronic diseases often presents alongside gastrointestinal symptoms. Research on the microbiome‐gut‐brain axis (MGBA) has emerged as a promising avenue for elucidating the pathophysiology of depression. In this study, bibliometric analysis tools, including HistCite, VOSviewer, CiteSpace, and the bibliometrix R package, were employed to comprehensively explore the MGBA‐depression connection. A comprehensive survey identified 980 relevant publications concerning the MGBA‐depression relationship, with a significant increase in research output observed since 2014. This analysis pinpointed five key factors within the MGBA‐depression domain: cytokines, maternal separation, neuroinflammation, probiotics, and the vagus nerve. The insights presented herein offer valuable perspectives on prevailing research models that investigate the intricate interplay among the microbiome, gastrointestinal system, and brain within the context of depression. Based on these findings, future investigations should prioritize developing microbial‐based interventions and innovative therapeutic modalities aimed at alleviating depression. By leveraging interdisciplinary collaboration and enhancing our understanding of MGBA–depression connections, we can pave pathways toward more effective treatments. Furthermore, improving outcomes for individuals with depression may be achieved by deepening our comprehension of the complex relationships between depression itself, the gut‐brain axis, and gastrointestinal microbiota.

show abstract

Interactions Between Antidepressants and Intestinal Microbiota

Xie

Kuang

et al. 2023

Neurotherapeutics

View full text Add to dashboard Cite

Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation

Cited by 8 publications

References 27 publications

Bibliometric and Visual Analysis of Research on the Links between the Microbiome-Gut-Brain axis and Depression

Bibliometric and Visual Analysis of Research on the Links between the Microbiome-Gut-Brain axis and Depression

Microbiome‐gut‐brain axis as a novel hotspot in depression

Interactions Between Antidepressants and Intestinal Microbiota

Contact Info

Product

Resources

About