Bait Matrix Flavor Preference by Mongoose (<i>Herpestes auropunctatus</i>) in Puerto Rico: Implications for Oral Rabies Vaccination

Berentsen, Are R.; Johnson, Shylo R.; VerCauteren, Kurt C.

doi:10.18475/cjos.v48i1.a8

Cited by 9 publications

(7 citation statements)

References 16 publications

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“…Mongoose-specific bait matrices for vaccine delivery are being studied to facilitate eventual implementation of vaccination through baiting. Recent trials showed cheese-flavoured baits were preferred over fish and coconut flavours (Berentsen et al 2014). Additional trials indicated mongooses investigate egg-flavoured baits (Figure 3) more frequently than non-flavoured baits (A. Berentsen, unpublished data).…”

Section: Management Approachmentioning

confidence: 98%

Diverse examples from managing invasive vertebrate species on inhabited islands of the United States

Engeman¹,

Avery²,

Shiels³

et al. 2017

Australasian Journal of Environmental Management

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Section: Management Approachmentioning

confidence: 98%

Diverse examples from managing invasive vertebrate species on inhabited islands of the United States

Engeman¹,

Avery²,

Shiels³

et al. 2017

Australasian Journal of Environmental Management

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“…Rabies virus strains from Grenada (Zieger et al 2014), Cuba (Nadin- Davis et al 2006), and Puerto Rico (Nadin-Davis et al 2008) suggest independent introduction of rabies to different Caribbean islands. No oral rabies vaccination program exists for mongooses, although research into potential oral rabies vaccine baits in the Caribbean has been conducted (Linhart et al 1993;Creekmore et al 1994;Berentsen et al 2014). With large populations of feral dogs and cats, along with no compulsory vaccination for kept domestic animals, risks of rabies transmission between mongooses, domestic animals, and, ultimately, humans remain high.…”

Section: Diseasementioning

confidence: 99%

Feral Cats

Lepczyk¹,

Duffy²

2017

Ecology and Management of Terrestrial Vertebrate Invasive Species in the United States

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“…Currently no wildlife ORV program exists in Puerto Rico. Research into rabies vaccines and various bait types for mongooses has been conducted with promising results suggesting an ORV program for mongooses is possible 5,6,7,8 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (<em>Herpestes Auropunctatus</em>) Sera for Use as an Oral Rabies Vaccination Biological Marker

Berentsen

Sugihara

Payne

et al. 2019

JoVE

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The small Indian mongoose (Herpestes auropunctatus) is a reservoir of rabies virus (RABV) in Puerto Rico and comprises over 70% of animal rabies cases reported annually. The control of RABV circulation in wildlife reservoirs is typically accomplished by a strategy of oral rabies vaccination (ORV). Currently no wildlife ORV program exists in Puerto Rico. Research into oral rabies vaccines and various bait types for mongooses has been conducted with promising results. Monitoring the success of ORV relies on estimating bait uptake by target species, which typically involves evaluating a change in RABV neutralizing antibodies (RVNA) post vaccination. This strategy may be difficult to interpret in areas with an active wildlife ORV program or in areas where RABV is enzootic and background levels of RVNA are present in reservoir species. In such situations, a biomarker incorporated with the vaccine or the bait matrix may be useful. We offered 16 captive mongooses placebo ORV baits containing ethyl-iophenoxic acid (et-IPA) in concentrations of 0.4% and 1% inside the bait and 0.14% in the external bait matrix. We also offered 12 captive mongooses ORV baits containing methyl-iophenoxic acid (me-IPA) in concentrations of 0.035%, 0.07% and 0.14% in the external bait matrix. We collected a serum sample prior to bait offering and then weekly for up to eight weeks post offering. We extracted Iophenoxic acids from sera into acetonitrile and quantified using liquid chromatography/mass spectrometry. We analyzed sera for et-IPA or me-IPA by liquid chromatography-mass spectrometry. We found adequate marking ability for at least eight and four weeks for et-and me-IPA, respectively. Both IPA derivatives could be suitable for field evaluation of ORV bait uptake in mongooses. Due to the longevity of the marker in mongoose sera, care must be taken to not confound results by using the same IPA derivative during consecutive evaluations.

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Bait Matrix Flavor Preference by Mongoose (Herpestes auropunctatus) in Puerto Rico: Implications for Oral Rabies Vaccination

Cited by 9 publications

References 16 publications

Diverse examples from managing invasive vertebrate species on inhabited islands of the United States

Diverse examples from managing invasive vertebrate species on inhabited islands of the United States

Feral Cats

Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (<em>Herpestes Auropunctatus</em>) Sera for Use as an Oral Rabies Vaccination Biological Marker

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