Baixas doses de hidrocortisona possuem ação protetora no choque hemorrágico em ratos

Abstract

CirurgiaEste é um artigo publicado em acesso aberto (Open Access) sob a licença Creative Commons Attribution, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que o trabalho original seja corretamente citado. Descritores: hidrocortisona; solução salina hipertônica; choque hemorrágico; isquemia; reperfusão; inflamação; gasometria; ratos. ARTIGO DESummary Purpose: To evaluate the hydrocortisone low-dose effects in hemorrhagic shock in rats. Methods: Twenty male Wistar rats were randomly distributed into 04 groups: Sham Group (GS); Shock group (CG), animals subjected to hemorrhagic shock; Group Hypertonic Saline 7.5% (GSH 7.5%), with volume replacement of saline solution at 7.5% after shock; Hydrocortisone Group (GH), animals received hydrocortisone after shock. Arterial blood gas samples and variations of the mean arterial blood pressure (MAP) were analyzed before the shock induction and after treatments. Intestinal samples were collected for histological analysis. Results: MAP was statistical significantly increased after treatment of the shock in GSH 7,5% (p=0.0001) and GH (p=0.0058) when compared to the CG. Regarding the arterial blood gas analysis, hydrocortisone increased pH of arterial blood in comparison to the GC (P=0.0372), lowered PaCO2 (p=0.0008), maintained higher levels of bicarbonate ions (p=0.0395) and lower levels of lactate (p=0.002). GH (p=0.02), as GSH7.5% (p=0.0147), showed less histological damage than the GC. Conclusion: Low dosages of hydrocortisone had protective effects against hemorrhagic shock in rats.

Effect of Copaiba Oil in Intestinal Mucosa of Rats Submitted to Hypovolemic Shock

“…The animals were kept in a warm environment at 36º C and resuscitated volumetrically with 0.9% saline at a dose of 10 ml/kg subcutaneously. Fifty minutes after the shock induction, the mean arterial pressure was measured and 0.1 ml of blood was collected for arterial blood gas analysis 23 through the fixed jelco in the right common carotid artery. After collection, was performed the ligation of in both artery stumps with 4-0 silk, and the skin was sutured with 5-0 nylon.…”

“…Several alternatives were evaluated aiming to reduce ischemic injury in the intestinal mucosa. For this, hypertonic saline solutions 13 and hydrocortisone 23 were used during volume resuscitation; medications such as pentoxifylline 18 and N-acetyl-cysteine 1 ; probiotics 22 ; and enteral nutritional therapy 14 . However, these methods had dubious or unhelpful effects.…”