Baker’s yeast mediated preparation of (10-alkyl-10H-phenothiazin-3-yl)methanols

Toşa, Monica Ioana; Paizs, Csaba; Majdik, Cornelia; Moldovan, Paula; Novák, Lajos; Kolonits, Pál; Szabó, Erika; Poppe, László; Irimie, Florin Dan

doi:10.1016/s1381-1177(02)00015-2

Cited by 19 publications

(4 citation statements)

References 13 publications

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“…Over the assay time frame phenothiazine sulfoxide was the major isolated metabolite (Figure 2-10). These results are similar to bioconversions of phenothiazine with the yeast C. elegans 78 , B. bassiana 111 , and the functional group conversions identified in the oxidation of phenothiazine drugs 79,83,84,116…”

Section: Metabolite Characterizationsupporting

confidence: 73%

“…, its metabolism has been thoroughly studied in mammals 82 . The oxidation of phenothiazine and substituted phenothiazine drugs has been studied in the lower fungi C. elegans 78 and endophytic fungi 79,83,84 . Thiophenes are building blocks in many agrochemicals, pharmaceuticals (lornoxicam), and electrically conductive polymers 86 .…”

Section: Sulfoxide Importancementioning

confidence: 99%

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Hydrocarbon and insecticide induction of Beauveria bassiana catalysis of organosulfur compounds

Nicolau-Manterola¹

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for their comments and encouragement, but also for their insight and questions which broadened my research. I am grateful for the support and encouragement of the CBE staff. Ms. Albrecht, Ms. Schnedler, Ms. Wheatley, and Ms. Potter played a key role in my success by facilitating access to resources, reminding me about essential academic deadlines, and helping me navigate graduate and department requirements. In addition, I am thankful to Ms. Potter for her interest in my well-being and her kind and empowering words throughout the years. My lab mates, Victoria Henry, Richard Gonzalez and Michael Delcau, were being supportive and great lab partners in and outside the lab. I want to thank Yuan Cheng and Ben Ungs for their help on the completion of my project. My sincere thanks also goes to Dr. Lynn Teesch and Vic Purcell who trained me in the use of the GC-MS equipment and advised me on better ways to improve product detection. Without their support it would not have been possible to conduct this research.

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Section: Metabolite Characterizationsupporting

confidence: 73%

Section: Sulfoxide Importancementioning

confidence: 99%

Hydrocarbon and insecticide induction of Beauveria bassiana catalysis of organosulfur compounds

Nicolau-Manterola¹

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“…The synthesis of aldehydes 1a-e was previously described. 19 All solvents were purified and dried by standard methods as required. 20 Amberlite IRA 904 was purchased from Acros and was conditioned as previously described.…”

Section: Methodsmentioning

confidence: 99%

Biocatalytic enantioselective preparation of phenothiazine-based cyanohydrin acetates: kinetic and dynamic kinetic resolution

Paizs¹,

Tähtinen²,

Toşa³

et al. 2004

Tetrahedron

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“…9 During the work-up and purification procedures the instability of N-substituted phenothiazin-3-yl-ethanols rac2a-d was observed. While at room temperature and neutral pH they are relatively stable, slowly decomposing compounds, at higher temperature or at lower pH the easy water elimination could be the explanation for the high instability of rac-2a-d.…”

Section: Chemical Synthesismentioning

confidence: 99%

Lipase-catalyzed kinetic resolution of racemic 1-(10-alkyl-10H-phenothiazin-3-yl)ethanols and their butanoates

Brem

Toşa

Paizs

et al. 2010

Tetrahedron: Asymmetry

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Baker’s yeast mediated preparation of (10-alkyl-10H-phenothiazin-3-yl)methanols

Cited by 19 publications

References 13 publications

Hydrocarbon and insecticide induction of Beauveria bassiana catalysis of organosulfur compounds

Hydrocarbon and insecticide induction of Beauveria bassiana catalysis of organosulfur compounds

Biocatalytic enantioselective preparation of phenothiazine-based cyanohydrin acetates: kinetic and dynamic kinetic resolution

Lipase-catalyzed kinetic resolution of racemic 1-(10-alkyl-10H-phenothiazin-3-yl)ethanols and their butanoates

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