Balance and Gait Abnormalities of a Child With West Nile Virus Infection

Moon, Troy D.; Nadimpalli, Adi; Martin, Emily B.; Ortiz, Myriam A; Dyke, Russell B. Van

doi:10.1097/01.inf.0000164704.05076.1c

Cited by 19 publications

(14 citation statements)

References 10 publications

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“…10 Although immunocompromised children seem to be at a higher risk of developing severe disease, 6 many of the severe cases described in the literature occurred in previously healthy children. 3,5,[11][12][13]15,16 Other host factors that may increase the risk of WNND in children are unknown.…”

Section: Discussionmentioning

confidence: 99%

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West Nile Virus Disease in Children, United States, 1999–2007

et al. 2009

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The epidemiological characteristics of WNV disease in children are similar to adult case subjects; however, WNND is more likely to manifest as meningitis in children than in older adults. WNV should be considered in the differential diagnosis for pediatric patients presenting with febrile illness, meningitis, encephalitis, or acute flaccid paralysis, particularly during seasonal outbreaks in endemic areas.

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Section: Discussionmentioning

confidence: 99%

“…2,9,[11][12][13][14][15][16] In the early 1980s, WNV was isolated from the brains of 3 children who died of encephalitis within the same state in India. 23 During an unusual outbreak in Sudan in 2002, all 31 of the probable cases identified were among children Ͻ13 years of age, with most cases in those aged Յ5 years.…”

Section: Discussionmentioning

confidence: 99%

West Nile Virus Disease in Children, United States, 1999–2007

et al. 2009

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“…Some WNV patients describe symptoms that may reflect a loss of proprioception (Moon et al, 2005) (Table 1), which is a declining sense of the relative position of neighboring parts of the body. The cerebellum is involved in coordinating this communication to motor functions.…”

Section: Introductionmentioning

confidence: 99%

Neurological approaches for investigating West Nile virus disease and its treatment in rodents

2013

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West Nile virus (WNV) has had a major public health impact since its emergence in the Western Hemisphere; in 2012, nearly 3000 cases of WN neuroinvasive disease were identified in the United States. The underlying mechanisms of WN neurologic disease can only be studied to a limited extent in patients, but can be investigated in much greater detail in animal models. In this paper, we describe how we and others have employed a variety of electrophysiological and neurological techniques to study experimental WNV infections in hamsters and mice. The methods have included electrophysiological motor unit number estimation; optogenetic photoactivation of the spinal cord and electromyography; plethysmography; measurement of heart rate variability as an indication of autonomic nervous system dysfunction; and an assessment of spatial memory loss using the Morris water maze. These techniques provide a more refined assessment of disease manifestations in rodents than traditional measurements of weight loss and mortality, and should make it possible to identify targets for therapeutic intervention and to directly assess the effects of novel treatments.

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“…been reported [106,107]. Similar to adults, children with immunocompromized status may be more susceptible to more severe illness [76].…”

Section: Manifestations Of Westmentioning

confidence: 95%

Manifestations of West Nile neuroinvasive disease

Sejvar

Marfin²

2006

Rev. Med. Virol.

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Since its introduction to North America in 1999, West Nile virus, an arthropod-borne flavivirus, has become the most significant cause of epidemic encephalitis in the western hemisphere. While most human infections with the virus are asymptomatic and the majority of symptomatic persons experience febrile illness, severe neurologic manifestations, including meningitis, encephalitis, and poliomyelitis may be seen. This review summarizes the virology, epidemiology and pathogenesis of human infection with West Nile virus, and details recent advances in our understanding of the pathophysiology and various clinical manifestations of infection.

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Balance and Gait Abnormalities of a Child With West Nile Virus Infection

Cited by 19 publications

References 10 publications

West Nile Virus Disease in Children, United States, 1999–2007

West Nile Virus Disease in Children, United States, 1999–2007

Neurological approaches for investigating West Nile virus disease and its treatment in rodents

Manifestations of West Nile neuroinvasive disease

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