2017
DOI: 10.1016/j.cnc.2017.04.003
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Balance Between the Proinflammatory and Anti-Inflammatory Immune Responses with Blood Transfusion in Sepsis

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Cited by 14 publications
(15 citation statements)
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“…As we did not tell apart invasive and non-invasive ventilation and the duration of ventilation was not recorded, the result should be interpreted cautiously. The association between blood transfusion and secondary infection of sepsis could be induced by transfusion-related immune modulation (TRIM) caused by the altered immune function [35][36][37][38]. However, transfusion was not found to be an independent risk factor in our study and it could be affected by type and quantity of transfusion.…”
Section: Discussioncontrasting
confidence: 63%
“…As we did not tell apart invasive and non-invasive ventilation and the duration of ventilation was not recorded, the result should be interpreted cautiously. The association between blood transfusion and secondary infection of sepsis could be induced by transfusion-related immune modulation (TRIM) caused by the altered immune function [35][36][37][38]. However, transfusion was not found to be an independent risk factor in our study and it could be affected by type and quantity of transfusion.…”
Section: Discussioncontrasting
confidence: 63%
“…It’s also proved by previous studies that the need for mechanical ventilation of critical ill patients incurred high prevalence of ventilator-associated pneumonia, which accounted for nearly half of nosocomial infections [3, 4, 37]. Blood transfusion was also a potential risk factor due to the effect of transfusion-related immune modulation (TRIM) as reveal by previous studies [3841]. Nevertheless, mechanical ventilation and blood transfusion were only found to be risk factors in univariate analysis of our study, but not multivariate analysis.…”
Section: Discussionmentioning
confidence: 81%
“…Under normal conditions, pro-inflammatory and antiinflammatory cytokines are in a dynamic balance at very low levels, thereby ensuring homeostasis. However, when sepsis occurs, a large number of pro-inflammatory and anti-inflammatory factors are released, leading to imbalance between the two factors, organ dysfunction and inflammatory damage to tissue cells [10,11].…”
Section: Discussionmentioning
confidence: 99%