Balance Control Improves Following Replacement of Paroxetine with Venlafaxine and Levodopa in a Case of Microvascular Dementia

McDonald, Jaime; Corbeil, Philippe; Pourcher, Emmanuelle

doi:10.1016/j.amjopharm.2011.03.002

Cited by 3 publications

(6 citation statements)

References 16 publications

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Section: Discussionsupporting

confidence: 94%

“…Antipsychotics impact on gait and balance is often dose specific and in future research, daily dosage of these medications should be considered. Rather, our study, similar to a recent finding by McDonald et al (2011), indicated that antidepressants were the only psychotropic medications associated with physical outcomes. Physiologically it is hypothesized that noradrenergic effects of some antidepressants contribute to alterations in balance and function (Debonnel et al 2006).…”

Section: Discussionsupporting

confidence: 90%

“…Antidepressants, including both tricyclics and selective serotonin reuptake inhibitors, have likewise been associated with falls (Darowski et al . 2009, McDonald et al . 2011), fracture (Spector et al .…”

mentioning

confidence: 99%

“…The increased risk of falls is believed to be due to sedating side effects, impairments in balance, orthostatic hypotension and cardiac arrhythmias associated with antidepressant use (Darowski et al . 2009, McDonald et al . 2011, Mehta et al .…”

mentioning

confidence: 99%

“…Antidepressants, including both tricyclics and selective serotonin reuptake inhibitors, have likewise been associated with falls (Darowski et al 2009, McDonald et al 2011), fracture (Spector et al 2007) and decreased sleep among older adults (Mayers & Baldwin 2005). The increased risk of falls is believed to be due to sedating side effects, impairments in balance, orthostatic hypotension and cardiac arrhythmias associated with antidepressant use (Darowski et al 2009, McDonald et al 2011, Mehta et al 2011.…”

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confidence: 99%

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Psychotropic medication use and association with physical and psychosocial outcomes in nursing home residents

Galik

Resnick

2012

Psychiatric Ment Health Nurs

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Psychotropic medications are commonly prescribed for older adults living in long-term care settings. Use of these medications has been associated with negative functional outcomes. The purpose of this study was to describe the prevalence of psychotropic medication use among nursing home residents, and to explore the relationship of psychotropic medication use on physical and psychosocial outcomes. A secondary data analysis was done using baseline measures from the Res-Care Intervention Study. The sample included 419 residents from 12 nursing homes. There were 288 participants (69%) who were prescribed at least one psychotropic medication, with 81 participants (19%) receiving antipsychotics, 248 (59%) receiving antidepressants, 50 (12%) receiving anxiolytics and 37 (9%) receiving sedative/hypnotics. Controlling for gender, age and cognition, physical outcomes were significantly lower in residents receiving psychotropic medications (F= 3.2, P= 0.01) compared to those not receiving psychotropic medications. Psychosocial outcomes were significantly lower in those residents receiving psychotropic mediations (F= 2.0, P= 0.04). The findings from this study provide additional support for the prevalence of psychotropic medication use among nursing home residents and suggest that residents receiving psychotropic medications may be less likely to engage in functional activities and experience decreased quality of life.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Psychotropic medication use and association with physical and psychosocial outcomes in nursing home residents

Galik

Resnick

2012

Psychiatric Ment Health Nurs

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Psychotropic Drug Use in Late Life: A Diverse Look at an Expanding Field

Blazer

2011

The American Journal of Geriatric Pharmacotherapy

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Changes in balance function with chronic antiepileptic drug therapy: A twin and sibling study

et al. 2015

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SUMMARYObjective: To investigate cross-sectional and longitudinal differences in static and dynamic standing balance measures and lower limb muscle strength in patients who are treated chronically with antiepileptic drugs (AEDs). Methods: Twenty-six AED exposure-discordant same-gender twin and sibling pairs were studied. Clinical and laboratory balance examinations were conducted twice, separated by at least 1 year. The mean within-pair differences in balance measures were calculated cross-sectionally at baseline and follow-up, and longitudinally. Results: No significant mean within-pair difference was found at baseline in age (44 years), weight, and height (p > 0.05). Between study assessments, the median (interquartile range [IQR]) interval was 3.0 (2.1-4.3) years in users and 2.9 (2.0-4.4) years in nonusers. The median duration of AED therapy was 19 (11-21) years.At baseline and follow-up, cross-sectional sway measures from posturography (Chattecx Balance System) and clinical static balance tests showed poorer performance in users compared to nonusers on several test conditions (p = 0.002-0.032). At follow-up, the users took longer than nonusers to complete the Four-Square-Step Test (p = 0.005) and Five-Times-Sit-to-Stand Test (p = 0.018).A greater annual rate of deterioration in sway was found in users compared to nonusers using posturography on the anteroposterior tilting platform task with distraction (p = 0.032). In both groups, higher baseline sway predicted greater annual deterioration in sway in all platform conditions (b = 0.3-0.5, p < 0.001-0.013). The annual change in measures did not differ between groups in the clinical balance and lower limb strength assessments. Significance: In this longitudinal twin and sibling study, chronic AED users had poorer standing balance compared to nonusers. Users showed greater deterioration in postural sway with one dynamic platform condition. AEDs may progressively impair balance mechanisms, although this requires further investigations. Repeated dynamic posturography could provide a basis for preventive trials for maintaining or improving balance.

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Balance Control Improves Following Replacement of Paroxetine with Venlafaxine and Levodopa in a Case of Microvascular Dementia

Cited by 3 publications

References 16 publications

Psychotropic medication use and association with physical and psychosocial outcomes in nursing home residents

Psychotropic medication use and association with physical and psychosocial outcomes in nursing home residents

Psychotropic Drug Use in Late Life: A Diverse Look at an Expanding Field

Changes in balance function with chronic antiepileptic drug therapy: A twin and sibling study

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