2018
DOI: 10.1111/jnc.14460
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Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system

Abstract: The heterotrimeric G-protein Go with its splice variants, Go1α and Go2α, seems to be involved in the regulation of motor function but isoform-specific effects are still unclear. We found that Go1α-/- knockouts performed worse on the rota-rod than Go2α-/- and wild-type (WT) mice. In Go1+2α-/- mice motor function was partially recovered. Furthermore, Go1+2α-/- mice showed an increased spontaneous motor activity. Compared to wild types or Go2α-/- mice, Go1+2α-/- mice developed increased behavioural sensitization … Show more

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“…Unfortunately, some authors still refuse to apply for the open science badges, even though no additional effort is required, other than signing the open science disclosure form. However, a number of manuscripts were already awarded with the Open Material Badge(Anderson et al 2018;Baron et al 2018;Dedoni et al 2018;Hastings et al 2018;Hausmann et al 2018;Ho et al 2018;Hopp et al 2018;Hunter et al 2018;Jacob et al 2018;Kanatsu et al 2018;Lautz et al 2018;Saba et al 2018;Saridaki et al 2018;Scholz et al 2018;Sharma et al 2018).…”
mentioning
confidence: 99%
“…Unfortunately, some authors still refuse to apply for the open science badges, even though no additional effort is required, other than signing the open science disclosure form. However, a number of manuscripts were already awarded with the Open Material Badge(Anderson et al 2018;Baron et al 2018;Dedoni et al 2018;Hastings et al 2018;Hausmann et al 2018;Ho et al 2018;Hopp et al 2018;Hunter et al 2018;Jacob et al 2018;Kanatsu et al 2018;Lautz et al 2018;Saba et al 2018;Saridaki et al 2018;Scholz et al 2018;Sharma et al 2018).…”
mentioning
confidence: 99%