Balance recovery is compromised and trunk muscle activity is increased in chronic obstructive pulmonary disease

Smith, Michelle D.; Chang, Angela; Hodges, Paul W.

doi:10.1016/j.gaitpost.2015.09.004

Cited by 37 publications

(41 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In support of this hypothesis, recent reports have shown that COPD in advanced stages is associated with an increased history of falls, balance impairment, and lower extremity muscle weakness. [65][66][67][68] Our results highlight that intercostal and intrinsic foot muscle Ca 21 signaling dysregulation occurs in cigarette smoke exposure. Understanding in more detail the pathophysiology of COPD and its effects in different skeletal muscles could help to further our knowledge of the natural history of the disease and to develop targeted treatments aimed to improve the performance of specific muscle groups.…”

Section: Limitations Of the Mouse Model Of Cigarette Smokementioning

confidence: 62%

See 1 more Smart Citation

Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD

et al. 2017

View full text Add to dashboard Cite

Introduction Respiratory and locomotor skeletal muscle dysfunction are common findings in chronic obstructive pulmonary disease (COPD), however, the mechanisms that cause muscle impairment in COPD are unclear. Because Ca2+ signaling in excitation-contraction (E-C) coupling is important for muscle activity, we hypothesized that Ca2+ dysregulation could contribute to muscle dysfunction in COPD. Methods Intercostal and flexor digitorum brevis muscles from control and cigarette smoke-exposed mice were investigated. We used single cell Ca2+ imaging and western blot assays to assess Ca2+ signals and E-C coupling proteins. Results We found impaired Ca2+ signals in muscle fibers from both muscle types, without significant changes in releasable Ca2+ or in the expression levels of E-C coupling proteins. Discussion Ca2+ dysregulation may contribute or accompany respiratory and locomotor muscle dysfunction in COPD. These findings are of significance to the understanding of the pathophysiological course of COPD in respiratory and locomotor muscles.

show abstract

Section: Limitations Of the Mouse Model Of Cigarette Smokementioning

confidence: 62%

“…We hypothesize that intrinsic foot muscle dysfunction could contribute to the increased susceptibility to falls in individuals with chronic COPD. In support of this hypothesis, recent reports have shown that COPD in advanced stages is associated with an increased history of falls, balance impairment, and lower extremity muscle weakness …”

Section: Discussionmentioning

confidence: 75%

Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Several reports indicated that decreases in the level of physical activity, which affect the prognosis of patients with COPD, can cause reduced balance ability 27–29. Compared with healthy individuals, COPD patients take a longer time to correct losses of balance while walking, and they require more trunk muscle activity 30. If patients with COPD fall and injure themselves, they may experience decreased physical functions, and their resulting reluctance to walk may lead to decreased levels of physical activity 31,32…”

Section: Discussionmentioning

confidence: 99%

New evaluation of trunk movement and balance during walking in COPD patients by a triaxial accelerometer

Terui¹,

Iwakura²,

Suto³

et al. 2018

COPD

View full text Add to dashboard Cite

BackgroundIndividuals with COPD may experience ambulatory difficulty due to both effort intolerance arising from respiratory dysfunction and impaired balance control during walking. However, the trunk movement during walking has not been evaluated or adjusted for patients with COPD. The Lissajous index (LI) visually and numerically evaluates the left–right symmetry of the trunk movement during walking and is useful in clinical practice. In COPD patients, the LI is used as an indicator of the left–right symmetry of the trunk during walking. Here, we used the LI to evaluate the symmetry of COPD patients based on bilateral differences in mediolateral and vertical accelerations, and we investigated the correlation between the patients’ symmetry evaluation results and their physical function.Patients and methodsSixteen stable COPD patients (all males; age 71.3±9.2 years) and 26 healthy control subjects (15 males; age 68.2±6.9 years) participated in this study. They performed the 10-minute walk test at a comfortable gait speed wearing a triaxial accelerometer, and we measured their trunk acceleration for the evaluation of symmetry. Motor functions were also evaluated in the patients with COPD.ResultsThe average mediolateral bilateral difference and LI values of the COPD patients were significantly larger than those of the healthy subjects. The COPD patients’ LI values were significantly correlated with their static balance.ConclusionThe LI measured using a triaxial accelerometer during walking is useful in balance assessments of patients with COPD.

show abstract

“…As another point of view, this recruitment pattern of superficial abdominal muscles during breathing with respiratory loads, observed in subjects ''At Risk" for the development of COPD, may impair the postural control. The excessive trunk muscle activity, namely abdominal muscles, in response to increased respiratory demand, can compromise the trunk moments/movements (Smith et al, 2016). Therefore, the reduced contribution of trunk movement to postural control may be the source to balance deficits that were reported in COPD subjects (Janssens et al, 2013;Smith et al, 2010).…”

Section: Future Investigationmentioning

confidence: 99%

The effect of inspiratory and expiratory loads on abdominal muscle activity during breathing in subjects “at risk” for the development of chronic obstructive pulmonary disease and healthy

Montes

Crasto

Melo

et al. 2017

Journal of Electromyography and Kinesiology

View full text Add to dashboard Cite

The abdominal muscle activity has been shown to be variable in subjects with chronic obstructive pulmonary disease (COPD) when respiratory demand increases and their recruitment pattern may change the mechanics, as well as the work and cost of breathing. The scientific evidence in subjects "at risk" for the development of COPD may be important to understand the natural history of this disease. This study aims to evaluate the effect of inspiratory and expiratory loads on the abdominal muscle activity during breathing in subjects "at risk" for the development of COPD and healthy. Thirty-one volunteers, divided in "At Risk" for COPD (n=17; 47.71±5.11years) and Healthy (n=14; 48.21±6.87years) groups, breathed at the same rhythm without load and with 10% of the maximal inspiratory or expiratory pressures, in standing. Surface electromyography was performed to assess the activation intensity of rectus abdominis (RA), external oblique and transversus abdominis/internal oblique (TrA/IO) muscles, during inspiration and expiration. During inspiration, in "At Risk" for COPD group, RA muscle activation was higher with loaded expiration (p=0.016); however, in Healthy group it was observed a higher activation of external oblique and TrA/IO muscles (p<0.050). During expiration, while in "At Risk" for COPD group, RA muscle activation was higher with loaded inspiration (p=0.009), in Healthy group TrA/IO muscle showed a higher activation (p=0.025). Subjects "at risk" for the development of COPD seemed to have a specific recruitment of the superficial layer of ventrolateral abdominal wall for the mechanics of breathing.

show abstract

Balance recovery is compromised and trunk muscle activity is increased in chronic obstructive pulmonary disease

Cited by 37 publications

References 34 publications

Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD

Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD

New evaluation of trunk movement and balance during walking in COPD patients by a triaxial accelerometer

The effect of inspiratory and expiratory loads on abdominal muscle activity during breathing in subjects “at risk” for the development of chronic obstructive pulmonary disease and healthy

Contact Info

Product

Resources

About