Balancing creep resistance and resilience in composites: Leveraging multidirectional and hierarchical structure of collagen fibres

Lei, Chao; Xu, Weixing; Zeng, Yunhang; Zhou, Jibo; Shi, Bi

doi:10.1016/j.compscitech.2024.110570

Cited by 3 publications

(2 citation statements)

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“…The arrangement of these fibers plays a crucial role in bone’s mechanical strength . Specifically, fibers aligned parallel to the direction of the load exhibit greater resistance to tension, while those perpendicular are more resistant to compression . The density and organization of the collagen network are critical for the adequate mineralization of bone .…”

Section: Introductionmentioning

confidence: 99%

“… 9 Specifically, fibers aligned parallel to the direction of the load exhibit greater resistance to tension, while those perpendicular are more resistant to compression. 10 The density and organization of the collagen network are critical for the adequate mineralization of bone. 11 Bone structure can vary, ranging from immature woven bone, characterized by a chaotic arrangement of loosely packed fibrils, to mature lamellar bone, which features densely packed collagen fibers aligned parallel within each lamella but with alternating orientations across lamellae.…”

Section: Introductionmentioning

confidence: 99%

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Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bamboo powders effectively reinforcing the modulus of PBAT composites and creep resistance

Ye,

Han

et al. 2024

Polymer Engineering & Sci

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Bamboo has a short growth cycle and exists in large quantities in nature. This paper uses bamboo powders (BP) to reinforce polybutylene adipate/terephthalate (PBAT) modulus and creep resistance. The BP was surface modified by γ‐(2,3‐epoxypropoxy)propyltrimethoxysilane (KH560), and compounded with PBAT in a twin‐screw extruder. The results showed that the specific surface area and micropores of BP were considerably higher than that of common wood powders and cellulose and contributes significantly to the modulus and the creep resistance of composites. Compared with pristine PBAT, the tensile modulus, flexural modulus of K‐BP/PBAT composites increased by 225%, 608%, respectively, at a filler content of 25 wt%. In addition, the creep resistance of K‐BP25 was improved by a factor of 3.25 compared to PBAT. The enhancement mechanism of K‐BP was discussed, the large specific surface area and micropores of K‐BP provided more anchoring sites, which effectively increased the interfacial binding force between K‐BP and PBAT, and enhanced the nucleation ability of PBAT, thus improving the modulus and creep resistance of the composites. The results of this paper broadened the scope of application of PBAT.Highlights The bamboo powders effectively reinforcing the modulus of PBAT. The bamboo powders effectively reinforcing the creep resistance of PBAT. The special feature of K‐BP can provide more anchoring sites for PBAT. The K‐BP improves the nucleation ability of PBAT.

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Correction to “Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration”

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Metrics & MoreArticle RecommendationsI n the published version of our review paper, we unintentionally omitted the citation for Figure 1(A). This panel was recreated from a figure published in an open access (CC BY 4.0) review article by de Wildt et al. (10.1016/ j.cobme.2019.05.005). We would like to correct the figure caption to properly attribute the original source. The corrected caption should read as follows: Figure 1. (A) Assembly of collagen from its fundamental structures to a complex network that forms the ECM within the bone. The organic matrix of bone is characterized by organized collagen fibrils at the nanometer scale and a densely aligned collagen fiber network at the micrometer scale. Reproduced from ref 17 , 2019, Elsevier, Inc. This work is licensed under a CC BY 4.0 license. (B) Second harmonic generation image depicting a densely packed and aligned collagen fiber network in human femoral cortical bone. This image vividly captures the robust and organized texture of collagen fibers within the network, highlighting their alignment and density, essential for the mechanical strength of bone (scale bar: 200 μm). Reproduced with permission from ref 18. Copyright Springer Nature 2017. (C) Electron microscopy image of cortical bone collagen fibrils. This high-resolution image provides a detailed view of the parallel alignment of individual collagen fibrils, underscoring the precision of molecular organization at the smallest scale within bone ECM. Reproduced with permission from ref 19. Copyright Elsevier 2000. Due to the addition of this new citation, the numbering of subsequent citations in the text has been adjusted accordingly. The original citation numbers of refs 1−16 are the same. References 17−209 are now refs 18−210. The reference list has been updated here to reflect these changes. The review's findings and content are unaffected by this change.

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Balancing creep resistance and resilience in composites: Leveraging multidirectional and hierarchical structure of collagen fibres

Cited by 3 publications

References 40 publications

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Bamboo powders effectively reinforcing the modulus of PBAT composites and creep resistance

Correction to “Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration”

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