2017
DOI: 10.1111/coin.12148
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Balancing exploration and exploitation in memetic algorithms: A learning automata approach

Abstract: One of the problems with traditional genetic algorithms (GAs) is premature convergence, which makes them incapable of finding good solutions to the problem. The memetic algorithm (MA) is an extension of the GA. It uses a local search method to either accelerate the discovery of good solutions, for which evolution alone would take too long to discover, or reach solutions that would otherwise be unreachable by evolution or a local search method alone. In this paper, we introduce a new algorithm based on learning… Show more

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Cited by 21 publications
(3 citation statements)
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“…The docking grid was set to dimensions of 60 Å × 60 Å × 60 Å with a grid spacing of 0.375 Å for site-specific docking (cavity). To obtain multiple conformations, the Lamarckian genetic algorithm [19] was utilized, simulating 20 different conformations over 25,000,000 steps. Molecular dynamics simulation: Firstly, the small molecule ligands optimized by Gaussian 16 software were converted to the required file format through an online conversion website http://davapc1.bioch.dundee.ac.uk/cgi-bin/prodrg (Accessed on 24 March 2018) [20].…”
Section: In Silico Methodsmentioning
confidence: 99%
“…The docking grid was set to dimensions of 60 Å × 60 Å × 60 Å with a grid spacing of 0.375 Å for site-specific docking (cavity). To obtain multiple conformations, the Lamarckian genetic algorithm [19] was utilized, simulating 20 different conformations over 25,000,000 steps. Molecular dynamics simulation: Firstly, the small molecule ligands optimized by Gaussian 16 software were converted to the required file format through an online conversion website http://davapc1.bioch.dundee.ac.uk/cgi-bin/prodrg (Accessed on 24 March 2018) [20].…”
Section: In Silico Methodsmentioning
confidence: 99%
“…However, GA lacks exploitation capability [ 18 ]; this means that GA cannot obtain the core subset of genes. Therefore, local search is incorporated into GA to enhance exploitation capability, and Memetic Algorithm (MA) is proposed [ 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…The goal of exploration is to ensure that a search is global and the goal of exploitation is to find best solution around a single solution. This is a kind of local search in which the goal of the memetic algorithm is to create a balance between the two concepts [14]. The basic GA has good exploration abilities because its basis is global when finding solutions.…”
Section: Introductionmentioning
confidence: 99%