Balancing the health benefits and environmental risks of pharmaceuticals: Diclofenac as an example

Acuña, Vicenç; Ginebreda, Antoni; Mor, Jordi‐René; Petrović, Mira; Sabater, Sergi; Sumpter, John P.; Barceló, Damià

doi:10.1016/j.envint.2015.09.023

Cited by 193 publications

(86 citation statements)

References 39 publications

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“…Among the emerging contaminants, pharmaceutical, diclofenac (DCF) is often detected in wastewater treatment plant influent, effluent, surface water and drinking water (Farré et al, 2008;Heberer, 2002;Stuart et al, 2012). It is estimated that about 1443 ± 58 tons of DCF are consumed globally on an annual basis (Acuña et al, 2015), which makes it as the 12 th bestselling generic molecule globally worth $1.61± 15% billion sales per year (Palmer, 2012). This large consumption, in turn, resulted in the ubiquitous presence of DCF in wastewater.…”

Section: Introductionmentioning

confidence: 99%

An insight into the adsorption of diclofenac on different biochars: Mechanisms, surface chemistry, and thermodynamics

Lonappan

Rouissi

Brar

et al. 2018

Bioresource Technology

218

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Biochars were prepared from feedstocks pinewood and pig manure. Biochar microparticles obtained through grinding were evaluated for the removal of emerging contaminant diclofenac (DCF) and the underlying mechanism were thoroughly studied. Characterization of biochar was carried out using particle size analyzer, SEM, BET, FT-IR, XRD, XPS and zeta potential instrument. Pig manure biochar (BC-PM) exhibited excellent removal efficiency (99.6%) over pine wood biochar (BC-PW) at 500 µg L of DCF (environmentally significant concentration). Intraparticle diffusion was found to be the major process facilitated the adsorption. BC-PW followed pseudo first-order kinetics whereas BC-PM followed pseudo second-order kinetics. Pine wood biochar was largely affected by pH variations whereas for pig manure biochar, pH effects were minimal owing to its surface functional groups and DCF hydrophobicity. Thermodynamics, presence of co-existing ions, initial adsorbate concentration and particles size played substantial role in adsorption. Various isotherms models were also studied and results are presented.

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Section: Introductionmentioning

confidence: 99%

An insight into the adsorption of diclofenac on different biochars: Mechanisms, surface chemistry, and thermodynamics

Lonappan

Rouissi

Brar

et al. 2018

Bioresource Technology

218

View full text Add to dashboard Cite

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“…Partly because of these high consumption rates, diclofenac has been detected in environmental samples (surface, ground, and drinking water) from at least 50 countries . More specifically, diclofenac has been measured in global wastewater and surface waters at concentrations ranging from low ng L −1 to low µg L −1 . Diclofenac has recently been placed on the European Union Water Framework Directive watch list , so that monitoring data can be collected to understand its environmental risk.…”

Section: Introductionmentioning

confidence: 99%

Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

McRae

Glover

Burket

et al. 2017

Enviro Toxic and Chemistry

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Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of growing concern in aquatic environments worldwide; nevertheless, knowledge of its effects on aquatic biota is restricted to a few model species with limited information regarding its mechanisms of impact. In the present study, diclofenac accumulation, its effects on metabolic rate, ionoregulation, and oxidative stress were examined at environmentally relevant (0.17 mg L À1 ) and elevated (763 mg L À1 ) concentrations in a culturally and economically important galaxiid fish, inanga (Galaxias maculatus), from the Southern Hemisphere. This species is among the most widespread freshwater fish in the world but its sensitivity to emerging contaminants is unknown. Following an acute 96-h exposure, bioconcentration of diclofenac was measured in the inanga whole-body, resulting in an estimated bioconcentration factor of 87 for the 0.17-mg L À1 exposure concentration, approaching values where transfer through the food chain should be considered. Lipid peroxidation in the liver was significantly elevated at both 0.17-and 763-mg L À1 exposure concentrations but lipid peroxidation in the kidney and gill decreased after diclofenac exposure. Catalase activity was also elevated in the liver of inanga but activity decreased in the gill. There were no effects of diclofenac on metabolic rate or ion (sodium and calcium) influx rates. These data indicate that toxicologically relevant adverse outcomes and bioconcentration of diclofenac at environmentally relevant levels warrant additional study in this important fish. Environ Toxicol Chem 2018;37:224-235. C 2017 SETAC

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“…All risk‐management actions have both risks and benefits . The challenge is to weigh risks and adverse consequences against benefits (see the text boxes A hypothetical example of risk assessment and risk management of multiple stressors under changing environmental conditions relative to a defined protection goal ; Examples of unintended consequences of risk mitigation actions ; and Examples of the monetary and nonmonetary costs of overly conservative risk estimates and remediation goals ).…”

Section: Risk Assessment Of Risk Managementmentioning

confidence: 99%

“…All risk-management actions have both risks and benefits [40,41]. The challenge is to weigh risks and adverse consequences against benefits (see the text boxes conservative risk estimates and remediation goals).…”

Section: Risk Assessment Of Risk Managementmentioning

confidence: 99%

Assessing and managing multiple risks in a changing world—The Roskilde recommendations

Selck

Adamsen

Backhaus

et al. 2016

Enviro Toxic and Chemistry

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Abstract-Roskilde University (Denmark) hosted a November 2015 workshop, Environmental Risk-Assessing and Managing Multiple Risks in a Changing World. This Focus article presents the consensus recommendations of 30 attendees from 9 countries regarding implementation of a common currency (ecosystem services) for holistic environmental risk assessment and management; improvements to risk assessment and management in a complex, human-modified, and changing world; appropriate development of protection goals in a 2-stage process; dealing with societal issues; risk-management information needs; conducting risk assessment of risk management; and development of adaptive and flexible regulatory systems. The authors encourage both cross-disciplinary and interdisciplinary approaches to address their 10 recommendations: 1) adopt ecosystem services as a common currency for risk assessment and management; 2) consider cumulative stressors (chemical and nonchemical) and determine which dominate to best manage and restore ecosystem services; 3) fully integrate risk managers and communities of interest into the risk-assessment process; 4) fully integrate risk assessors and communities of interest into the riskmanagement process; 5) consider socioeconomics and increased transparency in both risk assessment and risk management; 6) recognize the ethical rights of humans and ecosystems to an adequate level of protection; 7) determine relevant reference conditions and the proper ecological context for assessments in human-modified systems; 8) assess risks and benefits to humans and the ecosystem and consider unintended consequences of management actions; 9) avoid excessive conservatism or In This Issue: ET&C FOCUSFocus articles are part of a regular series intended to sharpen understanding of current and emerging topics of interest to the scientific community.

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Balancing the health benefits and environmental risks of pharmaceuticals: Diclofenac as an example

Cited by 193 publications

References 39 publications

An insight into the adsorption of diclofenac on different biochars: Mechanisms, surface chemistry, and thermodynamics

An insight into the adsorption of diclofenac on different biochars: Mechanisms, surface chemistry, and thermodynamics

Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

Assessing and managing multiple risks in a changing world—The Roskilde recommendations

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