Ball-lens assisted sensitivity improvement of fluorescence immunoassay in microchannels

Zhang, Qingquan; Li, Jiajia; Su, Yu-Ting; Pan, Xiaoyan; Gai, Hongwei

doi:10.1039/d1ra04360a

Cited by 1 publication

(1 citation statement)

References 34 publications

(36 reference statements)

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“…Therefore, BTGMs were used in the following experiments. Notably, a similar RI-dependent signal increase has been observed in previous reports on fluorescence ( Schwartz et al, 2010 ; Zhang Q. et al, 2021 ).…”

Section: Resultssupporting

confidence: 89%

Contactless and robust dielectric microspheres-assisted surface-enhanced Raman scattering sensitivity improvement for anthrax biomarker detection

Zhao

Han

et al. 2022

Front. Chem.

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This report presents a contactless and robust dielectric microspheres (DMs)-assisted surface enhanced Raman scattering (SERS) enhancement method to improve SERS detection sensitivity detection sensitivity. DMs that could focus and collect light were embedded within the polydimethylsiloxane (PDMS) film to avoid direct contact with the analytical solution and improve detection reliability. The as prepared DMs embedded PDMS DMs PD MS film was integrated with a microfluidic technique to enhance the SERS signal of a liquid substrate. Detection in microfluidic systems can reduce reagent consumption, shorten assay time, and avoid evaporation of the colloid substrate solution. The robustness and potential influencing factors of DMs PDMS film assisted SERS enhancement (DERS) were evaluated using 4-aminothiophenol (4-ATP) as the Raman probe. The sensing performance of the proposed method toward dipicolinic acid (DPA) was evaluated, and an evident signal intensification was obtained. Remarkably, the DMs PDMS film can also be implemented on solid substrates. A proof-of-concept experiment was performed by covering the DMs PDMS film directly over an AgNPs@Si solid substrate wherein a 5.7-fold sensitivity improvement was achieved.

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Section: Resultssupporting

confidence: 89%

Contactless and robust dielectric microspheres-assisted surface-enhanced Raman scattering sensitivity improvement for anthrax biomarker detection

Zhao

Han

et al. 2022

Front. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

Ball-lens assisted sensitivity improvement of fluorescence immunoassay in microchannels

Abstract: A contactless and ball-lens assisted sensitivity improvement method was present for the fluorescence or luminescence immunoassay in microchannel.

Cited by 1 publication

References 34 publications

Contactless and robust dielectric microspheres-assisted surface-enhanced Raman scattering sensitivity improvement for anthrax biomarker detection

Contactless and robust dielectric microspheres-assisted surface-enhanced Raman scattering sensitivity improvement for anthrax biomarker detection

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