Ball milling: a green mechanochemical approach for synthesis of Ni (II), Co (II) and Cu (II) complexes

Abstract

A series of Ni (II), Co (II) and Cu (II) complexes were synthesized with excellent yields via a one‐pot ball milling chelation reaction of those metals and β‐diketone. The process offers numerous advantages, such as better yield, short reaction time and mild reaction conditions. The computational studying was estimated to approve the geometry of the isolated solid compounds by applying density functional theory. The synthesized compounds were interpreted by using various spectroscopic techniques [infrared (IR), 1H‐NMR, 13C‐NMR, UV–visible, electron spin resonance (ESR) and mass spectrometry] together with some physical studies (molar conductance and magnetic susceptibility). The outcomes data displayed that the (HD1), (HD2) and (HD3) acted as neutral and/or mononegative bidentate ligands. The ESR as well as electronic spectra suggested the octahedral configuration for all isolated complexes, expect [Cu (HD2)(OAc)2]·2H2O has square planar structure. Also, the in vitro antimicrobial assay was done by using the well diffusion method for HD1, HD2, HD3 and their complexes.

Green synthesis approach for Fe (III), Cu (II), Zn (II) and Ni (II)‐Schiff base complexes, spectral, conformational, MOE‐docking and biological studies

“…It is interesting to build a relation between structural‐feature with its biological‐behavior . It is known that, the ability of compound to penetrate the cell‐membrane as well as its lipophilic capacity, is a great challenge in biological efficiency.…”

“…It is interesting to build a relation between structuralfeature with its biological-behavior. [3] It is known that, the ability of compound to penetrate the cellmembrane as well as its lipophilic capacity, is a great challenge in biological efficiency. The lipophilic characteristic facilitates interaction with biological systems, which lead to block active sites that inhibits the cell reproduction.…”

“…Ni (II), Co (II) and Cu (II) complexes were synthesized with high yields through using ball milling chelation approach with β‐diketone. After full characterization, their distinguish‐biological feature was recorded . Schiff base complexes known displaying broad biological feature as, VO (II) and Cu (II) complexes, which were synthesized extensively with Schiff base derivatives and also tested for their biological feature as well as DNA‐binding efficiency .…”

“…After full characterization, their distinguish-biological feature was recorded. [3] Schiff base complexes known displaying broad biological feature as, VO (II) and Cu (II) complexes, which were synthesized extensively with Schiff base derivatives and also tested for their biological feature as well as DNA-binding efficiency. [4][5][6] In this study, a green route of synthesis, was the considered approach, to synthesize new Schiff base complexes.…”

Mechanosynthesis and Photophysics of Colour-tunable Photoluminescent Group 13 Metal Complexes with Sterically Demanding 3,5-di-tert-butyl Substituted Salen and Salophen Ligands

“…3,4 In mechanochemistry, reactions between solids are promoted by the application of mechanical energy, and reactions that often are unfavourable or inaccessible in solutions can be readily performed. 5 The increasing momentum gained by the mechanochemical field is illustrated by its current widespread use in the development of new reaction methodologies, 6,7 synthesis of organometallic complexes, 8,9 main group compounds, 10 metal organic frameworks, 11 alloys, 12 composite materials, 13,14 and cocrystals. 15 .…”