Ballast Flow Characteristics of Discharging Pipeline in Shield Slurry System

Wang, Yang; Xia, Yimin; Xiao, Xuemeng; Xu, Huiwang; Chen, Peng; Zeng, Guiying

doi:10.3390/app9245402

Cited by 16 publications

(7 citation statements)

References 27 publications

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“…In addition, we further verified the biosafety of our phenolic HA patches in vitro and in vivo. We previously demonstrated that various primary cells and stem cells including hepatocytes, endothelial cells, neural stem cells, and mesenchymal stem cells were highly viable in HA‐CA hydrogels during culture 7a,8,38. We also reported that hADSCs grown within gallol‐modified HA hydrogel showed good viability more than 95% 7b.…”

Section: Resultsmentioning

confidence: 90%

Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy

Shin

Choi

Kim

et al. 2019

Adv Funct Materials

110

102

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Hydrogels have been applied to improve stem cell therapy and drug delivery, but current hydrogel-based delivery methods are inefficient in clinical settings due to difficulty in handling and treatment processes, and low off-the-shelf availability. To overcome these limitations, an adhesive hyaluronic acid (HA) hydrogel patch is developed that acts as a ready-to-use tissue tape for therapeutic application. The HA hydrogel patches functionalized with phenolic moieties (e.g., catechol, pyrogallol) exhibit stronger tissue adhesiveness, greater elastic modulus, and increased off-the-shelf availability, compared with their bulk solution gel form. With this strategy, stem cells are efficiently engrafted onto beating ischemic hearts without injection, resulting in enhanced angiogenesis in ischemic regions and improving cardiac functions. HA hydrogel patches facilitate the in vivo engraftment of stem cell-derived organoids. The off-the-shelf availability of the hydrogel patch is also demonstrated as a drug-loaded ready-made tissue tape for topical drug delivery to promote wound healing. Importantly, the applicability of the cross-linker-free HA patch is validated for therapeutic cell and drug delivery. The study suggests that bioinspired phenolic adhesive hydrogel patches can provide an innovative method for simple but highly effective cell and drug delivery, increasing the off-the-shelf availability-a critically important component for translation to clinical settings.

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Section: Resultsmentioning

confidence: 90%

Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy

Shin

Choi

Kim

et al. 2019

Adv Funct Materials

110

102

View full text Add to dashboard Cite

show abstract

“…With the burgeoning development in bioprinting techniques, it is expected that current limitations of spatial resolution, throughput, printability and biocompatibility will be diminished. Novel bioprinting approaches including scaffold‐free printing (direct 3D deposition and assembly of cells and cell spheroids into guided tissue architectures), [ 235,236 ] nanoscale matrix fabrication (electrospun fibers in bulk gels for guided EC assembly), [ 237–242 ] 4D printing (stimulus‐responsive materials that undergo programmed 3D conformational change over time postprinting) [ 243,244 ] and acoustophoretic printing (user‐controlled surface acoustic wave forms to pattern cell‐laden hydrogels in 3D space) [ 245,246 ] can also provide potential opportunities for fabrication of complex vascular networks. Further integration of bioprinted constructs with microfluidic platforms will facilitate the interrogation of vascular mechanobiology in organ‐mimetic microenvironments.…”

Section: Fabrication Strategies To Generate Microfluidic and Vascularmentioning

confidence: 99%

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Pradhan

Banda

Farino

et al. 2020

Adv Healthcare Materials

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The vascular system is integral for maintaining organ‐specific functions and homeostasis. Dysregulation in vascular architecture and function can lead to various chronic or acute disorders. Investigation of the role of the vascular system in health and disease has been accelerated through the development of tissue‐engineered constructs and microphysiological on‐chip platforms. These in vitro systems permit studies of biochemical regulation of vascular networks and parenchymal tissue and provide mechanistic insights into the biophysical and hemodynamic forces acting in organ‐specific niches. Detailed understanding of these forces and the mechanotransductory pathways involved is necessary to develop preventative and therapeutic strategies targeting the vascular system. This review describes vascular structure and function, the role of hemodynamic forces in maintaining vascular homeostasis, and measurement approaches for cell and tissue level mechanical properties influencing vascular phenomena. State‐of‐the‐art techniques for fabricating in vitro microvascular systems, with varying degrees of biological and engineering complexity, are summarized. Finally, the role of vascular mechanobiology in organ‐specific niches and pathophysiological states, and efforts to recapitulate these events using in vitro microphysiological systems, are explored. It is hoped that this review will help readers appreciate the important, but understudied, role of vascular‐parenchymal mechanotransduction in health and disease toward developing mechanotherapeutics for treatment strategies.

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“…Wang et al [10] used two-way coupling of FEM-DEM to check the characteristics of anomalistic ballast flow in slurry circulation system in the process of tunneling. The ballast size of 17~32 mm under various slurry velocities and ballast particle volume concentrations was studied to determine the impact law of slurry velocities, retention quality percent and ballast distribution.…”

Section: Introductionmentioning

confidence: 99%

Study on the particle movement characteristics and the pipe pressure drop of slurry shield circulation system

2023

Preprint

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Slurry circulating system is the core system for transporting excavated stone from the excavation interface, and the flow characteristics of stone in circulating pipeline is the key to determine whether stone can be transported smoothly. Based on Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) coupling method, the 3D pipe flow model was established, and the shape of the stone was considered in the model. The particle movement characteristics and the pipe pressure drop is studied. The simulation results indicate that the slurry velocity and slurrydensity have a significant effect on the particle movement characteristics. And the pressure loss along the horizontal straight pipeline is about 620 Pa/m. For the 20 m-high vertical pipeline model, its pressure loss along the vertical pipeline is about 1,100 Pa/m. The conclusions can be helpful for setting the working parameters of circulation system.

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Ballast Flow Characteristics of Discharging Pipeline in Shield Slurry System

Cited by 16 publications

References 27 publications

Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy

Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Study on the particle movement characteristics and the pipe pressure drop of slurry shield circulation system

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