Aspergillus is a ubiquitous mold found in diverse environments but is mostly limited to infectious complications in immunocompromised patients. Invasive pulmonary aspergillosis (IPA) is a common infection in leukemic patients with prolonged neutropenia. However, mycotic pulmonary artery aneurysm (PAA) is a very rare complication of IPA. We describe the case of a 58-year-old patient with prolonged neutropenia and leukemia who developed invasive aspergillosis, followed by unexpected massive hemoptysis and terminal exsanguination. Surgical resection of IPA in leukemic patients is rarely performed because of early recognition and initiation of preemptive potent antifungals, pancytopenia, bleeding diathesis, and delayed wound healing. Historically, tuberculosis and syphilis were major causes of PAA, but their incidence has decreased significantly since the advent of effective antibiotics. We review nontuberculous causes of PAA and outline the pathology, diagnosis, and treatment options currently available. Currently, Staphylococcus species, Streptococcus species, and Aspergillus species account for 70% cases of PAA.