Balneotherapy in osteoarthritis: Facts, fiction and gaps in knowledge

Fioravanti, Antonella; Bender, Tamás; Karagülle, Mine

doi:10.1016/j.eujim.2017.01.001

Cited by 92 publications

(51 citation statements)

References 19 publications

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“…In these studies, usually a selected method of balneology was investigated mainly in rheumatic diseases. These pieces of evidence confirm the experience-based use of balneotherapy (Bender et al 2014;Fioravanti et al 2017). Medical significance of the organic fractions of natural waters is still poorly understood.…”

Section: Introductionsupporting

confidence: 62%

Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds)

Szabó

Varga

2019

Int J Biometeorol

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Medicinal thermal waters consist of a mixture of different organic and inorganic compounds. Traditionally, these waters are only characterized and classified by their inorganic composition; however, the bioavailability of the majority of these inorganic compounds is limited. Many authors investigate the organic fractions of thermal waters. These authors propose that these compounds have a potential effect on health. To elucidate the underlying mechanisms, it is crucial to know the composition of the organic fractions. The absorption of these compounds on intact skin or mucosa is notable. Some of them have local anaesthetic effect or affect receptors in the central nervous system. In the knowledge of the chemical composition, we are able to estimate the possible pharmacological effect or might be able to assess possible toxicity risks. In the present article, we aim to review possible health effects of two of the identified organic fractions: benzene and alkylbenzenes and phenolic compounds that might correlate with the therapeutic effect on rheumatological or other diseases.

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Section: Introductionsupporting

confidence: 62%

Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds)

Szabó

Varga

2019

Int J Biometeorol

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“…Another critical point is the transport of the minerals through the skin layers and their accumulation in the joints. Unfortunately, only few investigations have been conducted on these topics and there is a little knowledge about the specific actions of different mineral waters [ 45 ]. Nagy et al previously reported an electrometric probe, developed to measure the H 2 S penetration through the skin of living experimental mouse [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models

Tékus

Borbély

Kiss

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Arthritic diseases are the most frequent causes of chronic pain and disability. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and progressive structural joint damage. Osteoarthritis is a degenerative process of the articular cartilage associated with hypertrophic changes in the bone. The aim of the present study was to investigate the anti-inflammatory and analgesic effects of Hévíz thermal water and mud in monosodium iodoacetate- (MIA-) (25 mg/ml, 20 μl i.a.) induced osteoarthritis and Complete Freund's adjuvant- (CFA-) (1 mg/ml, 50–50 μl s.c) induced rheumatoid arthritis murine models. The mechanonociceptive threshold of female NMRI mice (n=6– 8 mice/ group) was measured by aesthesiometry, and paw volume was monitored with plethysmometry, knee joint diameter with digital micrometer, and dynamic weight bearing on the hind limbs with a Bioseb instrument. Periarticular bone destruction was assessed by SkyScan 1176 in vivo micro-CT. Inflammatory cytokines were detected by ELISA in plasma samples. Treatments (30 min, every working day) with tap water, sand, and a combined therapy of tap water and sand served as controls. Hévíz medicinal water and combined treatment with water and mud significantly decreased the mechanical hyperalgesia and knee oedema in MIA-induced osteoarthritis model. However, balneotherapy did not influence mechanical hyperalgesia, weight bearing, or oedema formation induced by CFA. Neither medicinal water nor mud treatment ameliorated deep structural damage of the bones or the joints in the animal models. On the basis of the present findings, we conclude that balneotherapy is an effective complementary treatment to reduce the pain sensation and swelling in degenerative joint diseases such as osteoarthritis. Our experimental data are in agreement with the previous human studies that also confirmed antinociceptive and anti-inflammatory effects of thermal water and Hévíz mud treatments.

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“…Balneotherapy, 1 has been frequently used globally as a complementary and/or alternative therapy. [2][3][4][5] A recent systematic review (SR) showed that balneotherapy (BT) and spa therapy (ST) could significantly improve quality of life of patients with knee osteoarthritis.…”

Section: Introductionmentioning

confidence: 99%

<p>Overview of Systematic Reviews with Meta-Analysis Based on Randomized Controlled Trials of Balneotherapy and Spa Therapy from 2000 to 2019</p>

Kamioka

Nobuoka

Iiyama

2020

IJGM

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Background: The objectives of this review were to summarize systematic reviews with meta-analysis of balneotherapy (BT) and spa therapy (ST) based on randomized controlled trials, and to provide a perspective for future research. Methods: Eligible studies were systematic reviews based on randomized controlled trials with meta-analysis that included at least one group treated with BT or ST. We searched the following databases for articles published in English from the year 2000 to 20 November 2019: Cochrane Database Systematic Review, MEDLINE, CINAHL, Web of Science, and Ichushi-Web. Results: Eighteen studies met all inclusion criteria. Based on the International Classification of Diseases (ICD)-11, among these 18 studies, 8 (44%) were about "#15 Diseases of the musculoskeletal system or connective tissue", 5 (28%) were about "#21 Symptoms, signs or clinical findings, not elsewhere classified", 4 (22%) were about "#11 Diseases of the circulatory system", and 1 study (6%) was about "#8 Diseases of the nervous system". Both BT and ST provided significant pain relief and improved quality of life in chronic diseases of the musculoskeletal system and connective tissues. Additionally, BT and ST with exercise under water improved physical fitness and function in patients across diseases. Conclusion: Researchers need to conduct studies on the treatment of many kinds of potential diseases using the keywords of pain relief and QoL. In addition, depending on patients' symptoms, physical fitness, and disabilities, performing exercise under water may improve treatment effects on physical function and fitness.

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Balneotherapy in osteoarthritis: Facts, fiction and gaps in knowledge

Cited by 92 publications

References 19 publications

Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds)

Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds)

Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models

<p>Overview of Systematic Reviews with Meta-Analysis Based on Randomized Controlled Trials of Balneotherapy and Spa Therapy from 2000 to 2019</p>

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