Balsalazide Is Superior to Mesalamine in the Time to Improvement of Signs and Symptoms of Acute Mild-to-Moderate Ulcerative Colitis

Pruitt, Ronald E.; Hanson, John S.; Safdi, Michael; Wruble, Lawrence D.; Hardi, Robert; Johanson, John F.; Koval, George; Riff, Dennis; Winston, Barry; Cross, Amanda J.; Doty, Pamela; Johnson, Lorin K.

doi:10.1111/j.1572-0241.2002.07103.x

Cited by 100 publications

(53 citation statements)

References 22 publications

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“…57.32), as detailed earlier in this chapter. Head-to-head blinded randomized studies with equimolar doses of azo-bond release balsalazide and pH-release mesalamine have shown superior remission rates, earlier time to complete absence of symptoms, as well as other outcomes favoring balsalazide in some, but not all, studies [670][671][672]. Whether this benefit extends to other azo-bond release agents has not been firmly established [381,673].…”

Section: Mild Diseasementioning

confidence: 99%

Inflammatory Bowel Disease

Stenson

Hanauer

Cohen

2008

Textbook of Gastroenterology

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In the US, H. pylori vacA shows allelic variation in the signal sequence (which may be type sla, slb or s2) and the mid-region (type ml or m2). Previous PCR-based vacA mid-region typing classified most, but not all, Asian and South American strains tested as ml or m2. We now sought to investigate vacA mid-region diversity further.MotlmodL We studied 13 Japanese, 6 Chinese, 9 Thai, and 8 Peruvian H. pylori isolates. cagA was identified by colony hybridisation (CH), vacA signal sequence was typed by PCR, and vacA mid-region was typed proximally by CH and distally by PCR. Sections of the vacA mid-region from 8 strains were PCR-amplified, sequenced, and compared with known sequences from 8 other strains.Rcuts Of the 36 Asian and South American strains studied, 35 were cagA+ (the cagA-was Peruvian) and 35 were vacA sla (1 cagA + Peruvian was slb). vacA mid-regions from the 13 Japanese strains were not PCR-amplified by ml or m2-specific primers, but hybridised weakly with an ml probe. Sequence analysis of vacA from 1 Japanese strain revealed 91% nucleotide identity with the ml probe but only 71% identity with the m2 probe. The previously equivocal Thai and Peruvian strains also had ml-like mid-region sequences. A Chinese strain was ml in the proximal mid-region and m2 distally, showing a clear crossover site. Final mid-region types were: Japanese, all 13 ml; Chinese, 1 ml, 1 ml/m2, 4 m2; Thai, 3 ml, 6 m2; Peruvian 4 ml, 4 m2. Distal mid-region sequences of 16 strains, compared over 294 bp, clustered into 2 groups, ml and m2. Nucleotide identity between ml and m2 strains ranged from 73-78%. Within groups, m2 strains were less diverse than ml strains (m2 range 94-99.7%, ml 88-99.3%, p<0.001). Sequence analysis of 7 ml and 3 m2 strains over 1.1kb proximally showed maintenance of clustering outside the 294bp region C duions These Asian and South American strains are similar in terms of cagA status and vacA sla genotype, but fall into 2 vacA midregion groups. ml sequences are more diverse than m2, and thus may be phylogenetically older. The vacA sequence of 1 Chinese strain suggests recombination in vivo between ml and m2 alleles. Introduction: H.pylori antimicrobial susceptibility is an important determinant ofthe efficacy of eradication therapies'. The prevalence of antimicrobial resistance varies within the UK and may increase given the increased use of eradication therapy. This multicentre study assesses the prevalence and possible associations ofH.pylon antimicrobial resistance. Methods: H.pylon was isolated from antral biopsies of patients undergoing routine endoscopy and cultured according to standard microbiological methods. Antimicrobial resistance was determined using "E-tests" or disc tests (tinidazole only) with breakpoints defined by previous studies. Results: H.pyloni was isolated from 32% (1222/3823) of patients and antimicrobial susceptibility determined in 90% (1077/1222) Previous case-control studies of IBD have used hospital or community derived controls. There are obvious inherent biases in both metho...

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Section: Mild Diseasementioning

confidence: 99%

Inflammatory Bowel Disease

Stenson

Hanauer

Cohen

2008

Textbook of Gastroenterology

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“…The quality of the remaining studies was assessed by use of the Jadad score (Table 1). Of the six studies, five achieved Jadad a score of 3 or more [16][17][18][19][20] and other achieved a Jadad score of 2 [15]. Regarding the Cochran Q test for heterogeneity, it was found that all studies were homogenous and could be combined and meta-analyzed by fixed effects.…”

Section: Resultsmentioning

confidence: 99%

“…Two reports were considered ineligible, and thus, six trials remained ( Fig. 1) [15][16][17][18][19][20]. The quality of the remaining studies was assessed by use of the Jadad score (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The aminosalicylate balsalazide is a prodrug which is metabolized by bacterial azo reductases in the colon to release its therapeutically active moiety 5-ASA, mesalazine, and an inert carrier molecule (4-aminobenzoyl-b-alanine) [14]. Although the efficacy and safety of mesalazine and balsalazide have been compared in several clinical trials [15][16][17][18][19][20], no metaanalysis has yet been conducted. Meta-analysis is a statistical procedure for combining data from multiple studies and is necessary because only summary statistics are available in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Mesalazine and Balsalazide in Induction and Maintenance of Remission in Patients with Ulcerative Colitis: A Meta-Analysis

et al. 2008

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“…In addition, newer ASA derivates, such as balsalazide, were shown to be effective and safe for the treatment of mild-tomoderate colitis. 37 Patients who do not respond adequately to the standard dose should be treated at a higher dose. Should monotherapy with 5-ASA not prove satisfactory, combination treatment with local corticosteroids is recommended.…”

Section: Endoscopymentioning

confidence: 99%

Radiation-Induced Sequelae Affecting the Continence Organ: Incidence, Pathogenesis, and Treatment

Petersen

Jongen²,

Petersen

et al. 2007

Diseases of the Colon &Amp; Rectum

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Balsalazide Is Superior to Mesalamine in the Time to Improvement of Signs and Symptoms of Acute Mild-to-Moderate Ulcerative Colitis

Abstract: Balsalazide is an effective and safe treatment for mild-to-moderate ulcerative colitis. Improvement of symptoms occurs considerably earlier with balsalazide than with mesalamine.

Cited by 100 publications

References 22 publications

Inflammatory Bowel Disease

Inflammatory Bowel Disease

Comparison of Mesalazine and Balsalazide in Induction and Maintenance of Remission in Patients with Ulcerative Colitis: A Meta-Analysis

Radiation-Induced Sequelae Affecting the Continence Organ: Incidence, Pathogenesis, and Treatment

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