Baltic herring hydrolysates: Identification of peptides, in silico DPP-4 prediction, and their effects on an in vivo mice model of obesity

Wang, Dongxu; Huang, Xin; Marnila, Pertti; Hiidenhovi, Jaakko; Välimaa, Anna-Liisa; Granato, Daniel; Mäkinen, Sari

doi:10.1016/j.foodres.2024.114696

Food Research International

2024

DOI: 10.1016/j.foodres.2024.114696

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Baltic herring hydrolysates: Identification of peptides, in silico DPP-4 prediction, and their effects on an in vivo mice model of obesity

Dongxu Wang,

Xin Huang,

Pertti Marnila

et al.

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Cited by 2 publications

References 33 publications

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Screening, identification, and mechanistic exploration of DPP-IV inhibitory peptides from collagen in Esox lucius skin

Li,

Wei,

Lei

et al. 2025

Food Bioscience

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Screening, identification, and mechanistic exploration of DPP-IV inhibitory peptides from collagen in Esox lucius skin

Li,

Wei,

Lei

et al. 2025

Food Bioscience

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Marine Peptides: Potential Basic Structures for the Development of Hybrid Compounds as Multitarget Therapeutics for the Treatment of Multifactorial Diseases

Bauer,

Glowacka,

Kamysz

et al. 2024

IJMS

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Marine-derived peptides display potent antihypertensive, antioxidant, analgesic and antimicrobial biological effects. Some of them have also been found to have anticancer activity via various mechanisms differing from those of continental organisms. This diversity of properties—together with the peptides’ efficacy, which has been confirmed in several in vitro and in vivo studies—make these compounds attractive as functional ingredients in pharmacy, especially in regard to multitarget drugs known as hybrids. Given the possibilities offered by chimeric structures, it is expected that a hybridization strategy based on a marine-derived compound could result in a long-awaited success in the development of new effective compounds to combat a range of complex diseases. However, despite the fact that the biological activity of such new hybrids may exceed that of their parent compounds, there is still an urgent need to carefully determine their potential off-targets and thus possible clinically important side effects. Given the above, the aim of this paper is to provide information on compounds of marine origin with peptide structures and to verify the occurrence and usage of hybrid compounds built from these structures. Furthermore, the authors believe that information presented here will serve to increase public awareness of the new opportunities arising from the combination of hybridization strategies with marine molecules with known structures and biological properties, thereby accelerating the development of effective drug candidates.

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Baltic herring hydrolysates: Identification of peptides, in silico DPP-4 prediction, and their effects on an in vivo mice model of obesity

Cited by 2 publications

References 33 publications

Screening, identification, and mechanistic exploration of DPP-IV inhibitory peptides from collagen in Esox lucius skin

Screening, identification, and mechanistic exploration of DPP-IV inhibitory peptides from collagen in Esox lucius skin

Marine Peptides: Potential Basic Structures for the Development of Hybrid Compounds as Multitarget Therapeutics for the Treatment of Multifactorial Diseases

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