2020
DOI: 10.26599/tst.2019.9010064
|View full text |Cite
|
Sign up to set email alerts
|

BAM: A block-based Bayesian method for detecting genome-wide associations with multiple diseases

Abstract: Many human diseases involve multiple genes in complex interactions. Large Genome-Wide Association Studies (GWASs) have been considered to hold promise for unraveling such interactions. However, statistic tests for high-order epistatic interactions (2 Single Nucleotide Polymorphisms (SNPs)) raise enormous computational and analytical challenges. It is well known that the block-wise structure exists in the human genome due to Linkage Disequilibrium (LD) between adjacent SNPs. In this paper, we propose a novel Ba… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(3 citation statements)
references
References 31 publications
0
3
0
Order By: Relevance
“…The area under the ROC curve is AUC. Moreover, a series of broader assessment criteria [25,26] , including the area under the precise-recall curve (AUPR), F1-measure (F1), accuracy (ACC), specificity (SPE), recall (REC), and precision (PRE), are used for more comprehensive and equitable evaluation of proposed models.…”
Section: Evaluation Metricsmentioning
confidence: 99%
“…The area under the ROC curve is AUC. Moreover, a series of broader assessment criteria [25,26] , including the area under the precise-recall curve (AUPR), F1-measure (F1), accuracy (ACC), specificity (SPE), recall (REC), and precision (PRE), are used for more comprehensive and equitable evaluation of proposed models.…”
Section: Evaluation Metricsmentioning
confidence: 99%
“…For example, a powerful forward often means the decrement of whole team's defense ability as the forward is often not willing to take part in the defense job. In view of this exampled observation, an association rulebased similarity calculation and matching approach is brought forth in [31][32].…”
Section: A Similarity-based Matchingmentioning
confidence: 99%
“…However, the above comprehensive score calculation solutions are often confronted with a big challenge, i.e., they often assume that the involved multiple sport training scores are independent with each other. While actually, for different sport items, their training scores are often correlated with each other [7][8][9][10] . For example, a player who swims well often has high lung vital capacity; and therefore, he or she is prone to get a higher training score when taking the running sport.…”
Section: Introductionmentioning
confidence: 99%