Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism

Zhou, Xiaolu; Pak, SolJu; Li, Daotong; Li, Dong; Chen, Fang; Hu, Xiaosong; Ma, Lingjun

doi:10.3390/foods12071380

Cited by 12 publications

(5 citation statements)

References 48 publications

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“…30,31 In contrast, Blautia and Faecalibaculum have been documented to show a positive association with obesity and impaired glucose tolerance. 32 The results at the species level were consistent with those observed at the corresponding genus level. These findings suggested that ACN from Lycium ruthenicum Murray exerts its anti-obesity effect on female mice through the regulation of the gut microbiota, specifically by increasing the abundances of beneficial bacteria such as Allobaculum, Lactobacillus_johnsonii and Lactobacillus_reuteri within Firmicutes.…”

Section: Discussionsupporting

confidence: 83%

Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism

Li,

Zhang,

Tan

et al. 2024

Natural Product Communications

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Objectives Female obesity may be improved by the consumption of a high-polyphenolic-rich diet. Lycium ruthenicum Murray is a renowned edible plant, the fruit of which is abundant in anthocyanins and exhibits many biological activities. This study aimed to investigate the potential impact of anthocyanins derived from Lycium ruthenicum Murray (ACN) intervention on improving obesity by regulating the gut microbiota and bile acids (BAs) metabolism in high-fat diet (HFD)-induced female mice. Methods A total of 32 C57BL/6J female mice were divided into four distinct groups: the Ctrl group (fed a normal diet), Ctrl + ACN group (fed a normal diet plus 8 mg/mL extract of ACN), HFD group (fed a high-fat diet), and HFD + ACN group (fed a HFD plus 8 mg/mL extract of ACN). Results The findings showed that ACN significantly reduced the body weight, periovarian adipose mass, and adipocyte diameter, ameliorated lipid accumulation in the liver, and lowered the serum total cholesterol and low-density lipoprotein (LDL-C) levels in HFD-induced female mice. In addition, ACN exhibited a reversal of gut microbial dysbiosis in HFD-fed female mice, such as by enhancing the quantity of Lactobacillus and Allobaculum and reducing the abundance of Blautia and Faecalibaculum. Moreover, the results of fecal BAs showed that ACN led to a decrease in the ratio of primary to secondary BAs, mainly attributed to decreased levels of primary BAs, including CA, CDCA, αMCA, and HCA in HFD-induced female mice. Further analysis revealed that ACN may exert its anti-obesity effect by increasing the relative abundance of Lactobacillus_ jonsonii and Lactobacillus_reuteri within the gut and subsequently affecting the metabolism of fecal HDCA and GUDCA. Conclusion These results indicated that ACN effectively inhibits HFD-induced obesity in female mice by regulating gut microbiota-related BA metabolism.

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Section: Discussionsupporting

confidence: 83%

Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism

Li,

Zhang,

Tan

et al. 2024

Natural Product Communications

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“…A previous study found that another omnivorous animal, lizard individuals, also harbored significantly more Methanobrevibacter [49]. Muribaculaceae, a short-chain fatty acid (SCFA)-producing bacteria [50], was associated with a high-fat diet and has been demonstrated in piglets [51]. Paludibacteraceae was another abundant family in the marmot, and it was connected with low protein and branched-chain amino acids in pigs [52].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Gut Microbiomes in Laboratory Chinchillas, Ferrets, and Marmots: Implications for Pathogen Infection Research

Guo,

Shi,

et al. 2024

Microorganisms

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Gut microbes play a vital role in the health and disease of animals, especially in relation to pathogen infections. Chinchillas, ferrets, and marmots are commonly used as important laboratory animals for infectious disease research. Here, we studied the bacterial and fungal microbiota and discovered that chinchillas had higher alpha diversity and a higher abundance of bacteria compared to marmots and ferrets by using the metabarcoding of 16S rRNA genes and ITS2, coupled with co-occurrence network analysis. The dominant microbes varied significantly among the three animal species, particularly in the gut mycobiota. In the ferrets, the feces were dominated by yeast such as Rhodotorula and Kurtzmaniella, while in the chinchillas, we found Teunomyces and Penicillium dominating, and Acaulium, Piromyces, and Kernia in the marmots. Nevertheless, the dominant bacterial genera shared some similarities, such as Clostridium and Pseudomonas across the three animal species. However, there were significant differences observed, such as Vagococcus and Ignatzschineria in the ferrets, Acinetobacter and Bacteroides in the chinchillas, and Bacteroides and Cellvibrio in the marmots. Additionally, our differential analysis revealed significant differences in classification levels among the three different animal species, as well as variations in feeding habitats that resulted in distinct contributions from the host microbiome. Therefore, our data are valuable for monitoring and evaluating the impacts of the microbiome, as well as considering potential applications.

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“…The results indicated the protective roles of the supplements on gut microbiota dysbiosis in aging mice. At genus levels, norank_f__Muribaculaceae 36) , Lactobacillus 37) , unclassified_f__Lachnospiraceae, norank_f__Lachnospiraceae 38) , Lachnospiraceae_ UCG-006 39) , Alistipes 40) , Streptococcus 41) , Rikenellaceae_ RC9_gut_group 42) , unclassified_f__Prevotellaceae 43) are SCFAs-producing bacteria, which are beneficial for liver health and are reported to be negatively associated with hepatic oxidative stress, inflammation and damage 44) . Norank_f__norank_o__Clostridia_UCG-014 45) , and Pre-votellaceae_UCG-001 46) are beneficial bacteria, that are reported to exert anti-inflammatory function and are inversely correlated with pro-inflammatory cytokines, like IL-6 and TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin, <i>Haematococcus pluvialis</i> and <i>Haematococcus pluvialis</i> Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis

Zhang,

Gao,

Zhu

et al. 2024

J. Oleo Sci.

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tive diseases, and liver diseases 1) . Liver is an important organ that is essential for maintaining whole-body metabolic homeostasis. The process of aging leads to gradual damage to the structure and function of liver 2) . One of the most accepted mechanisms underlying aging is oxidative Abstract: Astaxanthin is a keto-based carotenoid mainly obtained from marine organisms, like Haematococcus pluvialis (H. pluvialis). Previous studies indicated the protective effects of Astaxanthin and H. pluvialis on aging related oxidative injury in liver, while the potential mechanisms are largely unknown. In addition, H. pluvialis residue is a by-product after astaxanthin extraction, which is rarely studied and utilized. The present study aimed to compare the effects of astaxanthin, H. pluvialis and H. pluvialis residue on the oxidant injury of liver in D-galactose-induced aging mice and explore the potential mechanisms through gut-liver axis. The results showed that all the three supplements prevented D-galactose-induced tissue injury, oxidative stress and chronic inflammation in liver and improved liver function. Gut microbiota analysis indicated that astaxanthin notably increased fecal levels of Bacteroidetes, unclassified_f__ Lachnospiraceae, norank_f__Lachnospiraceae, norank_f__norank_o__Clostridia_UCG-014, Prevotellaceae_ UCG-001, unclassified_f__Prevotellaceae in D-galactose-fed mice (p < 0.05). Compared to aging mice, H. pluvialis group had higher fecal levels of norank_f__Lachnospiraceae and Lachnospiraceae_UCG-006 (p < 0.05). H. pluvialis residue group displayed higher relative levels of Bacteroidetes, Streptococcus, and Rikenellaceae_RC9_gut_group (p < 0.05). Moreover, the production of fecal microbial metabolites, like SCFAs and LPS was also differently restored by the three supplements. Overall, our results suggest astaxanthin, H. pluvialis and H. pluvialis residue could prevent aging related hepatic injury through gutliver axis and provide evidence for exploiting of H. pluvialis residue as a functional ingredient for the treatment of liver diseases. Future studies are needed to further clarify the effect and mechanism of dominant components of H. pluvialis residue on liver injury, which is expected to provide a reference for the high-value utilization of H. pluvialis resources.

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Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism

Cited by 12 publications

References 48 publications

Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism

Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism

Comparative Analysis of Gut Microbiomes in Laboratory Chinchillas, Ferrets, and Marmots: Implications for Pathogen Infection Research

Astaxanthin, <i>Haematococcus pluvialis</i> and <i>Haematococcus pluvialis</i> Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis

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