Banaba (Lagerstroemia speciosa L.)

Ulbricht, Catherine; Dam, Chi; Milkin, Tamara; Seamon, Erica; Weissner, Wendy; Woods, Jen

doi:10.1300/j157v07n01_09

Cited by 5 publications

(1 citation statement)

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“…Corosolic acid (CA) is a pentacyclic triterpenoid found predominantly in the leaves of Lagerstroemia speciosa L., commonly known as banaba . Accumulating evidence suggests that CA has anticancer effects through interfering with several processes, such as cell proliferation, angiogenesis, invasion, metastasis, and apoptosis. − CA induced apoptosis in gastric cancer by inhibiting the NF-κB pathway and in colorectal cancer by activating mitochondria-mediated and caspase-dependent pathways with decreased expression levels of p65, Fas, caspase -8, -9, and -3, and Bcl-2 and increased expression of Bax .…”

Section: Introductionmentioning

confidence: 99%

Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells

Jedram,

Maphanao,

Karnchanapandh

et al. 2023

ACS Omega

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Cholangiocarcinoma (CCA), an aggressive malignancy arising from the biliary epithelium, exhibits a high incidence in Thailand. CCA usually lacks specific symptoms and is typically diagnosed in its advanced stages, presenting significant treatment challenges. Current CCA therapeutic options, including surgery, chemotherapy, and radiation, have limited success rates and often cause side effects. Nature-derived compounds hold promise for reducing undesirable adverse effects and are an excellent source of anticancer drugs. Corosolic acid (CA), a triterpenoid found in Lagerstroemia speciosa L. leaves, exhibits anticancer properties; however, the effectiveness of CA against CCA and its molecular mechanisms remained unexplored. Herein, the anti-CCA and apoptosis-inducing effects of CA were investigated using various techniques, i.e., the MTT assay, flow cytometry with FITC-labeled Annexin V (Annexin V-FITC) and propidium iodide double staining, JC-1 staining, western blot analysis, caspase-3 activity assay, and molecular dynamics (MD) simulations. CA inhibited the proliferation of KKU-213A and KKU-213B CCA cells and triggered apoptosis through alterations in mitochondrial membrane potential (ΔΨm), and increases in the Bax/Bcl-2 expression ratio, cytochrome c release, and caspase-3 activity. As indicated by MD simulations, CA has the potential to bind to Bcl-2 through hydrogen bonds between amino acid residues R146 and N143. These findings underscore the potential of CA as a promising candidate for treatment of CCA.

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Section: Introductionmentioning

confidence: 99%

Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells

Jedram,

Maphanao,

Karnchanapandh

et al. 2023

ACS Omega

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Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosaL.) and Corosolic Acid

Miura

Takagi

Ishida

2012

Evidence-Based Complementary and Alternative Medicine

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Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This paper summarizes the current literature regarding Banaba and its constituents. The hypoglycemic effects of Banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects, and in vitro systems using water soluble Banaba leaf extracts, corosolic acid, and ellagitannins. Corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic and antioxidant activities. The beneficial effects of Banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis, and the regulation of lipid metabolism. These effects may be mediated by PPAR and other signal transduction factors. Banaba extract, corosolic acid, and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits.

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Review of the Safety and Efcacy of Banaba (Lagerstroemia speciosa L.) and Its Major Constituents, Corosolic Acid and Ellagitannins, in the Management of Metabolic Syndrome

Preuss¹,

Bagchi²,

Kaats³

2012

Obesity

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Banaba (Lagerstroemia speciosa L.)

Abstract: This study is an evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

Cited by 5 publications

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Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells

Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells

Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosaL.) and Corosolic Acid

Review of the Safety and Efcacy of Banaba (Lagerstroemia speciosa L.) and Its Major Constituents, Corosolic Acid and Ellagitannins, in the Management of Metabolic Syndrome

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Banaba (Lagerstroemia speciosa L.)

Abstract: This study is an evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

Cited by 5 publications

References 0 publications

Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells

Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells

Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosaL.) and Corosolic Acid

Review of the Safety and Ef­cacy of Banaba (Lagerstroemia speciosa L.) and Its Major Constituents, Corosolic Acid and Ellagitannins, in the Management of Metabolic Syndrome

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Product

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About

Review of the Safety and Efcacy of Banaba (Lagerstroemia speciosa L.) and Its Major Constituents, Corosolic Acid and Ellagitannins, in the Management of Metabolic Syndrome