2016
DOI: 10.1002/mrm.26236
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Band inversion amplifies31P-31P nuclear overhauser effects: Relaxation mechanism and dynamic behavior of ATP in the human brain by31P MRS at 7 T

Abstract: Purpose To develop an improved method to measure 31P nuclear Overhauser effect (NOE) for evaluation of ATP dynamics in terms of correlation time (τc), and contribution of dipole-dipole (DD) and chemical shift anisotropy (CSA) mechanisms to T1 relaxation of ATP in human brain. Methods The NOE of ATP in human brain was evaluated by monitoring changes in magnetization in the β-ATP signal following a band inversion of all downfield 31P resonances. The magnetization changes observed were analyzed using the Bloch-… Show more

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Cited by 12 publications
(27 citation statements)
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“…In addition to kinetic rate constants, the integrated fitting also provides quantitative measurements for ATP 31 P T 1 and cross‐relaxation in the resting human brain. The cross‐relaxation rate constant σ value was found to be −0.19 ± 0.04 s −1 , which is consistent with our previous results (−0.21 s −1 ) obtained by long‐TR band inversion Module III . The σ‐derived ATP rotation correlation time τ c was measured (0.8 ± 0.2) ·10 −7 s. ATP T 1 relaxation time was 0.7 to 1.0 s, which is significantly shorter than that found for Pi (7.3 s) and PCr (6.0 s).…”
Section: Discussionsupporting
confidence: 90%
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“…In addition to kinetic rate constants, the integrated fitting also provides quantitative measurements for ATP 31 P T 1 and cross‐relaxation in the resting human brain. The cross‐relaxation rate constant σ value was found to be −0.19 ± 0.04 s −1 , which is consistent with our previous results (−0.21 s −1 ) obtained by long‐TR band inversion Module III . The σ‐derived ATP rotation correlation time τ c was measured (0.8 ± 0.2) ·10 −7 s. ATP T 1 relaxation time was 0.7 to 1.0 s, which is significantly shorter than that found for Pi (7.3 s) and PCr (6.0 s).…”
Section: Discussionsupporting
confidence: 90%
“…A similar trend was observed previously in the human brain and skeletal muscle . The relative shorter T 1 relaxation time in ATP 31 P spins was attributed primarily to the presence of the chemical shift anisotropy effect in ATP .…”
Section: Discussionsupporting
confidence: 87%
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