Bandwidth and Common Mode Optimization for Current and Voltage Sources in Bioimpedance Spectroscopy

Abstract

Bioimpedance measurements use current or voltage sources to inject an excitation signal into the body. These sources require a high bandwidth, typically from 1 kHz to 1 MHz. Besides a low common mode, current limitation is necessary for patient safety. In this paper, we compare a symmetric enhanced Howland current source (EHCS) and a symmetric voltage source (VS) based on a non-inverting amplifier between 1 kHz and 1 MHz. A common mode reduction circuit has been implemented in both sources. The bandwidth of each source was optimized in simulations and achieved a stable output impedance over the whole frequency range. In laboratory measurements, the output impedance of the EHCS had its -3 dB point at 400 kHz. In contrast, the VS reached the +3 dB point at 600 kHz. On average over the observed frequency range, the active common mode compensation achieved a common mode rejection of -57.7 dB and -71.8 dB for the EHCS and VS, respectively. Our modifications to classical EHCS and VS circuits achieved a low common mode signal between 1 kHz and 1 MHz without the addition of complex circuitry, like general impedance converters. As a conclusion we found VSs to be superior to EHCSs for bioimpedance spectroscopy due to the higher bandwidth performance. However, this only applies if the injected current of the VS can be measured.

Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics

“…Constant current approaches such as the enhanced Howland pump [ 84 ] are commonly used to limit current for TUT safety and reliably address variable electrode-to-TUT (E2TUT) contact impedance [ 85 ]. However, constant voltage techniques have been found to offer higher bandwidths [ 86 ]. Despite these challenges, BI/BIS has been implemented in several clinical applications, including the detection and monitoring of edema.…”