According to the World Health Organization (WHO), cardiovascular diseases (CVDs) are the leading causes of death worldwide, with one third of deaths attributed to CVDs in 2012. Pulmonary oedema and pleural effusion are the most apparent symptoms of many diseases categorized under CVDs such as heart failure and lung cancer, at which fluid (mainly with high water content) is accumulated in or around the lungs. Therefore, constant monitoring of fluid levels inside the lungs is one of the most efficient ways of early detection of CVDs. Chest X-Rays and computational tomography (CT)-scans are the most widely used devices for fluid detection; however, they suffer from lack of sensitivity and ionizing radiation, respectively, that makes them unsuitable for long term monitoring purposes. Currently, magnetic resonance imaging (MRI) is the most reliable device that can be utilized for fluid accumulation detection. However, considering the fact that more than 75% of the CVDs occur in countries with low or middle income, it is not widely available. Moreover, due to their bulky structures, the abovementioned devices lack the capability of being used in mobile emergency units such as ambulances or clinics at rural areas. To that end, this thesis is dedicated to design and fabrication of a low cost, portable and non-invasive device that can be used as an initial decision making tool for medical staff to pursue further investigations to define the exact cause of the oedema.First chapter of the thesis is allocated to introduction of the cardiovascular diseases and their effects on the dielectric properties of the tissues inside the lungs. A complete literature review on various alternative methods for replacing the conventional devices is performed. The obtained results by these systems and their advantages as well as their limitations are discussed. Microwave imaging technique is then presented in chapter two as a robust method which can both provide information about the presence and location of the accumulated fluid. This is specifically of great importance for cases where biopsy is required to remove or take sample of the accumulated fluid for saving the life of the patient. Chapter two is also allocated to the introduction of microwave-based medical diagnostic and monitoring systems for different applications such as breast cancer detection and brain imaging. A prospect of the possible realizable systems is investigated and existing scanning approaches are discussed. The main contributions of the thesis that are the design of several complete platforms, design of novel and unidirectional microwave sensors (antennas), promotion of novel scanning and detection methods are clarified in these chapters.In chapter three, firstly the optimum operating frequency for torso imaging is defined. By applying a circuit model that models different layers of torso as circuit elements, it is shown that a wide operating bandwidth at lower ultra-high frequency (UHF) band provides a reasonable III compensation between the resolution of...