This study investigates using the phononic crystal with periodically closed resonators as a greenhouse gas sensor. The transfer matrix and green methods are used to investigate the dispersion relation theoretically and numerically. A linear acoustic design is proposed, and the waveguides are filled with gas samples. At the center of the structure, a defect resonator is used to excite an acoustic resonant peak inside the phononic bandgap. The localized acoustic peak is shifted to higher frequencies by increasing the acoustic speed and decreasing the density of gas samples. The sensitivity, transmittance of the resonant peak, bandwidth, and figure of merit are calculated at different geometrical conditions to select the optimum dimensions. The proposed closed resonator gas sensor records a sensitivity of 4.1 Hz m−1 s, a figure of merit of 332 m−1 s, a quality factor of 113,962, and a detection limit of 0.0003 m s−1. As a result of its high performance and simplicity, the proposed design can significantly contribute to gas sensors and bio-sensing applications.