"Bangle Rhizome Extract Promotes Hippocampal Neurogenesis Associated with Improved Cognitive Functions: A Case Study"

Abstract

Bangle Rhizome Extract (BRE) promotes neurogenesis of human neural stem cells and improves spatial learning memory in ageing model mice. In the present case study, we applied BRE to a 53-year-old female patient with mild memory impairment for 6 weeks. We examined cognitive functions, P300 Electroencephalogram (EEG) signals, and MRI signals before and after the administration of BRE. Spatial memory, working memory, attention, and reaction time were improved after BRE administration in association with hippocampal neurogenesis. EEG recordings showed improved electrical abnormalities with increased neural connections and enhanced EEG responses in attention and visual spatial memory tests. MRI showed the fusion of fragmented tissues in the hippocampus after BRE administration, which represents morphological changes observed in the regenerative process of the hippocampus. This is the first clinical case report that BRE promotes neurogenesis and regeneration of the hippocampus associated with improved cognitive functions.