Banking of Heart Valves

Parker, Robert L.

doi:10.1007/978-90-481-9142-0_5

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…This was particularly relevant for slow-growing organisms, such as the common skin contaminant, Propionibacterium acnes [9]. However, it is recognised that disinfecting tissues at this lower temperature has the advantages of reducing bacterial proliferation, as well as preventing warm ischemia damage to the tissue [9, 10]. To minimise potential ischemic damage, most HVBs that incubated allografts at 37°C used an incubation time of ≤12 hours [7].…”

Section: Discussionmentioning

confidence: 99%

International Heart Valve Bank Survey: A Review of Processing Practices and Activity Outcomes

Heng

Albrecht

Chiappini

et al. 2013

Journal of Transplantation

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A survey of 24 international heart valve banks was conducted to acquire information on heart valve processing techniques used and outcomes achieved. The objective was to provide an overview of heart valve banking activities for tissue bankers, tissue banking associations, and regulatory bodies worldwide. Despite similarities found for basic manufacturing processes, distinct differences in procedural details were also identified. The similarities included (1) use of sterile culture media for procedures, (2) antibiotic decontamination, (3) use of dimethyl sulfoxide (DMSO) as a cryoprotectant, (4) controlled rate freezing for cryopreservation, and (5) storage at ultralow temperatures of below −135°C. Differences in procedures included (1) type of sterile media used, (2) antibiotics combination, (3) temperature and duration used for bioburden reduction, (4) concentration of DMSO used for cryopreservation, and (5) storage duration for released allografts. For most banks, the primary reasons why allografts failed to meet release criteria were positive microbiological culture and abnormal morphology. On average, 85% of allografts meeting release criteria were implanted, with valve size and type being the main reasons why released allografts were not used clinically. The wide variation in percentage of allografts meeting release requirements, despite undergoing validated manufacturing procedures, justifies the need for regular review of important outcomes as cited in this paper, in order to encourage comparison and improvements in the HVBs' processes.

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Section: Discussionmentioning

confidence: 99%

International Heart Valve Bank Survey: A Review of Processing Practices and Activity Outcomes

Heng

Albrecht

Chiappini

et al. 2013

Journal of Transplantation

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“…Seventy-five percent of allografts are used in paediatric cases, a further 15% in adult congenital cardiac surgery and the final 10% in adult acquired cardiac surgery, particularly in redo operations and patients with bacterial or fungal endocarditis. 14 The main pros and cons of using human cardiac allografts are shown in Table 5.…”

Section: Other Tissue Banking Activitymentioning

confidence: 99%

The organization of tissue banking in Scotland

Galea

2012

Scott Med J

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Tissue banking in Scotland has developed significantly over the past 20 years or so. The range of issues procured has increased and so have their numbers. Initially, bone from live donors was the only tissue banked; later, tissues from multiorgan donors were procured; this was finally followed by the collection of tissues from donors following cardiac death. Bones, tendons, heart valves and skin are the main tissue types collected, stored and issued for clinical use. Much of our activity is based on identification of donors in two major accident and emergency departments followed by retrievals that take place in a dedicated mortuary by fully-trained staff. Tissues are released according to clinical need for Scottish patients and beyond. All of the tissue banking activity in Scotland takes place within the Scottish National Blood Transfusion Service, which is the preferred provider of tissues for Scottish patients. There is very close cooperation between our teams, the transplant teams and other clinical colleagues, including pathologists and anatomical technicians. The achievements in issue banking in Scotland are outlined along with the main clinical indications of the tissue procured. Diversification is now taking place into cellular therapy with the establishment of an islet processing programme and cell culturing techniques. The future is very exciting.

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“…Afterwards, Donald Ross, in 1962, was the pioneering surgeon whom carried out the first homograft implantation in the cardiac position 2 . Thereafter, prosthetic heart valves were launched and used in the 1960s before xenografts came along in the 1970s 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Compared with mechanical valves, allografts have better hemodynamic performance, low thromboembolic rates without anticoagulation, no mechanical damage to blood cells, and low frequency of post-operative endocardititis, but limited durability 3 , 6 , 7 , 8 . Considering the pros and cons of homografts, these tissue valves are more cost-benefit and affordable for a majority of settings worldwide.…”

Section: Introductionmentioning

confidence: 99%

Iranian homograft tissue processing

Rouchi

Tavakoli

Mahdavi‐Mazdeh

2016

gcsp

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Tissue transplantation is a life-enhancing therapeutic modality for damaged or non-functioning tissues. In most cases, there is no alternative other than human tissue as replacement, and taking into account the ever-increasing demand for tissue grafts, it makes sense to set up an establishment in charge of human tissue procurement to meet local needs. A quality assurance system, clearly defined standards, and regular audits complement the infrastructure which make this activity feasible. The process of tissue procurement consists of donor identification, consent, tissue recovery, donor screening and testing, tissue processing, preservation, packaging, labeling, terminal sterilization, storage and distribution. The transplantation of homograft heart valves remains controversial, due to the availability of prosthetic and bioprosthetic alternatives. The limited durability of homografts has not yet outweighed the advantages which this graft offers. Adherence to regulations and regularly revised guidelines improve long-term efficacy and minimizes complications or malfunction. Furthermore, the lower price of homograft heart valves and the removal of the need for a lifetime of anticoagulation therapy are noteworthy advantages of this replacement. In our practice, the proportion of homograft heart valves meeting release criteria and successfully implanted grafts were 83% and 95%, respectively.

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Banking of Heart Valves

Cited by 6 publications

References 36 publications

International Heart Valve Bank Survey: A Review of Processing Practices and Activity Outcomes

International Heart Valve Bank Survey: A Review of Processing Practices and Activity Outcomes

The organization of tissue banking in Scotland

Iranian homograft tissue processing

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