BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells

B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1

“…BAP1 is known to play an important cell-intrinsic role in T cell development in the thymus, as well as in the peripheral T cell expansion under homeostatic conditions and in response to antigenic stimulation ( 48 ). Furthermore, BAP1 activities in mesenchymal stromal cells (MSCs) are essential for normal B cell development in the bone marrow ( 106 ). Therefore, in addition to the cell intrinsic roles of BAP1 in B cells, elucidated in our current work, BAP1 functions in T cells and stromal compartments need to be considered when assessing its systemic roles in the regulation of humoral immunity in vivo , as for example in carriers of germline BAP1 mutations.…”

Identification of mitophagy-related hub genes during the progression of spinal cord injury by integrated multinomial bioinformatics analysis

“…Studies have found that BAP1 is critical for T cell development at several stages [ 54 ] and maintaining hematopoietic stem cells and B lymphopoiesis. Mice lacking BAP1 in bone marrow mesenchymal stromal cells show aberrant differentiation of hematopoietic stem and progenitor cells, impaired B lymphoid differentiation, and expansion of myeloid lineages [ 55 ]. In our study, we found that regulatory T cells (Tregs) and resting NK cells were upregulated, which may be associated with chronic inflammation.…”