Barbiturate Induction for the Prevention of Emergence Agitation after Pediatric Sevoflurane Anesthesia

Use, Tadasuke; Nakahara, Haruna; Kimoto, Ayako; Beppu, Yuki; Yoshimura, Maki; Kojima, Toshiyuki; Fukano, Taku

doi:10.5863/1551-6776-20.5.385

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Such drugs are highly volatile and have a unique fruity fragrance. The difficulty of using the medicine is significantly reduced [5,6]. Compared with other volatile anaesthetics, SEV minimizes the irritation of the upper respiratory tract of children, significantly shortening the time it takes for the drug to take effect and wash out [7].…”

Section: Introductionmentioning

confidence: 99%

Influence of Dexmedetomidine on Clinical Efficacy of General Anesthesia and Stress Response in Children

LIANG¹

2022

FARMACIA

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This study was aimed to explore the effect of dexmedetomidine (DEX) nose drops on paediatric general anaesthesia in the resuscitation room and its influence on children's postoperative stress. Sixty-eight children undergoing general anaesthesia were enrolled. They were randomly divided into two groups according to admission, with 34 cases in each group. Children in the experimental group received DEX at a 1µg/kg dose as nasal drops, combined with sevoflurane (SEV) anaesthesia. Children in the control group received 0.4 mL saline as nasal drops, combined with SEV anaesthesia. Mean arterial pressure (MAP) and heart rate (HR) were recorded before induction of anaesthesia (T0), during extubation (T1), 5 min (T2), and 15 min after extubation (T3). In addition, venous blood was sampled at each of the above time points to determine the plasma epinephrine (E), norepinephrine (NE), and cortisol (Cor) levels to evaluate the postoperative stress response. The incidence of adverse reactions in the two groups was counted. The rate of crying at T1, restlessness after awakening, and adverse reactions were significantly reduced in children from the experimental group compared with the control group. The induction time of anaesthesia in children in the experimental group was significantly decreased compared with the control group. There was no considerable difference in the awakening time of the two groups of children, and the stay time in the post-anaesthesia care unit (PACU) was not extended. In addition, the children in the experimental group had lower MAP and HR at the time of extubation and 5 minutes after extubation compared with the control group. At T1 and T2, the changes of plasma E, NE, and Cor in children from the experimental group were significantly decreased compared with the levels in the control group. RezumatAcest studiu și-a propus să exploreze efectul picăturilor nazale cu dexmedetomidină (DEX) asupra anesteziei generale pediatrice și influența acestuia asupra stresului postoperator al copiilor. În studiu au fost incluși 68 de copii, randomizați în două grupuri. Copiii din grupul experimental au primit DEX la o doză de 1 µg/kg sub formă de picături nazale, în combinație cu anestezie cu sevofluran (SEV). Copiii din grupul de control au primit 0,4 mL ser fiziologic sub formă de picături nazale, combinate cu anestezie SEV. S-au înregistrat valorile tensiunii arteriale medii (MAP) și frecvența cardiacă (HR) înainte de inducerea anesteziei (T0), în timpul extubației (T1), la 5 minute (T2) și la 15 minute după extubare (T3). În plus, s-au recoltat probe de sânge pentru fiecare dintre momentele de mai sus pentru a determina nivelurile plasmatice de epinefrină (E), norepinefrină (NE) și cortizol (Cor), în scopul evaluării răspunsului la stres postoperator. S-a evaluat, de asemenea, incidența reacțiilor adverse în cele două grupuri. Timpul de inducere a anesteziei la copiii din grupul experimental a fost semnificativ redus comparativ cu grupul de control. Nu a existat o diferență considerabilă în timpul de trezire al ce...

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Section: Introductionmentioning

confidence: 99%

Influence of Dexmedetomidine on Clinical Efficacy of General Anesthesia and Stress Response in Children

LIANG¹

2022

FARMACIA

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Effect of dexmedetomidine combined with sufentanil on preventing emergence agitation in children receiving sevoflurane anesthesia for cleft palate repair surgery

Luo

Cao

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to observe whether dexmedetomidine (DEX) combined with sufentanil decreased emergence agitation (EA) in children receiving sevoflurane anesthesia for cleft palate repair surgery. Children undergoing elective cleft palate repair surgery were randomly allocated into the DEX + sufentanil group (group DS; n=50) and the normal saline + fentanyl group (group SF; n=50). Patients in group DS were treated with 0.5 µg/kg DEX prior to induction of anesthesia, whereas patients in group SF received an equal volume of normal saline. Sufentanil (0.2 µg/kg) was administered to induce anesthesia, and 30 min before the end of surgery for patients in group DS. Fentanyl (2 µg/kg) was administered at the same time point for patients in group SF. Mean arterial pressure (MAP), heart rate (HR), duration of surgery and anesthesia, and the dosage of remifentanil were assessed. EA score, Pediatric Anesthesia Emergence Delirium (PAED) score and the Children and Infants Postoperative Pain Scale (CHIPPS) score were documented every 15 min in the post-anesthesia care unit (PACU). The number of cases requiring fentanyl (1 µg/kg) and the recovery profile data were analyzed. Compared with group DS (P<0.05) and the baseline (P<0.05), HR and MAP were significantly increased in group SF immediately following tracheal intubation and extubation. Mean values of maximum EA, PAED and CHIPPS scores were significantly reduced in group DS compared with group SF at 0 (P<0.01), 15 (P<0.05), and 30 min (P<0.05) after arrival at PACU. The incidence of EA in group SF was significantly increased compared with group DS (P<0.05). The dosage of remifentanil during the surgery and the number of cases requiring fentanyl (1 µg/kg) in group DS were significantly decreased compared with group SF (P<0.05). The findings of the present study suggested that DEX combined with sufentanil was able to effectively decrease the incidence of EA in children receiving sevoflurane anesthesia for cleft palate repair surgery.

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Barbiturate Induction for the Prevention of Emergence Agitation after Pediatric Sevoflurane Anesthesia

Cited by 2 publications

References 32 publications

Influence of Dexmedetomidine on Clinical Efficacy of General Anesthesia and Stress Response in Children

Influence of Dexmedetomidine on Clinical Efficacy of General Anesthesia and Stress Response in Children

Effect of dexmedetomidine combined with sufentanil on preventing emergence agitation in children receiving sevoflurane anesthesia for cleft palate repair surgery

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