Barbituric and thiobarbituric acid-based UiO-66-NH2 adsorbents for iodine gas capture: Characterization, efficiency and mechanisms

Accurately Controlled Delivery of Temozolomide by Biocompatible UiO-66-NH2 Through Ultrasound to Enhance the Antitumor Efficacy and Attenuate the Toxicity for Treatment of Malignant Glioma

“…The UiO-66-NH2 MOFs have a mean size of ~150 nm (Figure S1), and their zeta potential is ~9.8 mV. The XRD patterns well match with the typical peaks of (111), (002) and (006) crystal planes of UiO-66-NH 2 (Figure 1D), 4,15,17 proving successful synthesis of the nanomaterials. The XRD patterns also according to other research about the UiO-66-NH 2 .…”

“…The Fourier transform infrared (FTIR) spectra of UiO-66-NH 2 shows adsorption bands at 1381 cm −1 and 1257 cm −1 , which correspond to the C-N stretching vibration. The adsorption bands at 1569 cm −1 and 3442 cm −1 are assigned to the OCO asymmetric stretching vibration and asymmetric N-H stretching vibration (Figure 1E) 4,18 respectively. These results confirmed that UiO-66-NH 2 have been successfully prepared.…”

“…MOFs is a new class of crystalline porous materials constructed by metal ions/clusters and organic linkers. 4 Due to internal circulation stability, high loading capacity, and excellent biocompatibility, MOFs provide an unprecedented opportunity for the treatment of cancer. 5 Especially, the nanoscale MOF of UiO-66-NH 2 can be as an ideal drug-delivery nanoparticle because it has superior cavity volume and slow-release functions, 6 which is expected to penetrate the blood-brain barrier (BBB).…”

“…UiO-66-NH 2 nanoparticle is a zirconiumbased framework constructed by Zr and 2-amino-1,4-benzenedicarboxylic acid (BDC-NH2) with octahedral microporous structure, exhibiting great chemical and thermal stability. 4 To design MOF nanocomposites as carriers for controllable drug release, various factors such as hydrophobicity, pH, temperature, biomolecular reactions, light and ultrasound are considered. 7 Among them, ultrasound-mediated targeted drug delivery has shown excellent properties for pinpointing the location, penetration, and controllable energy.…”

Cover Feature: Capture of Gaseous Iodine in Isoreticular Zirconium‐Based UiO‐n Metal‐Organic Frameworks: Influence of Amino Functionalization, DFT Calculations, Raman and EPR Spectroscopic Investigation (Chem. Eur. J. 14/2022)

“…These compounds constructed from the hexanuclear {Zr6O4(OH)4} poly-oxo/hydroxo cluster, offer a great opportunity to study the combined effect of porosity and functionalization for the molecules capture. This well-known MOF family has been previously studied for its iodine sorption kinetic properties by analyzing the influence of different parameters, such as the impact of structure defects in UiO-66, [22] the addition of alkyne group on the ditopic carboxylate linker in UiO-n derivatives, [20] the functionalization of the amino group by barbituric or thiobarbituric acid group in UiO-66_NH2, [23] or the effect of the structural types related to the occurrence of hexanuclear {Zr6O4(OH)4} bricks (UiO-66, UiO-67, MOF-808, NU-1000). [24] These reports dealt with the use of iodine vapor generated in a closed cell, in contact with the considered powdered UiO-n compounds, which are then weighted for the estimation of iodine uptake.…”