Bardoxolone Ameliorates Cerebral Ischemia/ Reperfusion Injury in Male Rats

Al-Mudhaffer, Rihab H; Al-Huseini, Laith M Abbas; Hassan, Saif M.; Hadi, Najah R

doi:10.36295/asro.2019.220415

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…The researchers discovered that after 48 hours, resveratrol drastically reduced the levels of HIF-1α in three distinct types of cells. They also observed a close correlation between the levels of VEGF in cells treated with resveratrol and HIF-1a protein expression levels in cells exposed to hypoxia or resveratrol treatment [36], [37], these findings aligned with ours.…”

Section: Discussionsupporting

confidence: 89%

Resveratrol can Reduce the Aggressiveness of Hypoxic Colon Cancer Cells

AlMudhafar,

Abed,

Hadi

et al. 2024

Azb Pharm Pharmaco J

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Colorectal cancer is a significant global health problem characterized by the development of metastasis due to fast cell growth, tolerance to low oxygen levels, and the formation of new blood vessels. Notable advancements have been seen in the management of these instances; however, uncertainties persist about drug resistance and its accompanying adverse effects. Resveratrol, a natural polyphenol derived from several plants, has diverse pharmacological characteristics. The anticancer impact of this has piqued the curiosity of several researchers. The objective of our research was to investigate the impact of resveratrol on the proliferation, migration, and expression of angiogenic factors in hypoxic colorectal cancer cells by the use of resveratrol. Hypoxia was chemically induced using cobalt chloride. Serially diluted concentrations of resveratrol (200, 100, 50, 25, 12.5, and 6.25 \(\mu\)g/ml) were employed to assess the cytotoxic effect through the MTT assay. Smaller concentrations (below IC50) were utilized to investigate the impact of resveratrol on the migration of SW480 cells using the wound healing assay (50 \(\mu\)g/ml). The impact of resveratrol on the expression of vascular endothelial growth factor (VEGF) was assessed using the enzyme-linked immunosorbent assay (ELISA). The findings shown that resveratrol has the ability to effectively decrease cell proliferation in a dose-dependent way, inhibit cell migration and angiogenesis, via suppression of VEGF and HIF-1\(\alpha\). The significance of this etude lies in the enduring inability to effectively manage metastatic colorectal cancer. Suggesting that resveratrol might function as an adjunctive therapy and a useful supplement for those suffering from very metastatic colorectal cancer. The specific method by which resveratrol works is yet unknown, hence more study is needed to conduct experiments in living organisms and clinical trials.

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Section: Discussionsupporting

confidence: 89%

Resveratrol can Reduce the Aggressiveness of Hypoxic Colon Cancer Cells

AlMudhafar,

Abed,

Hadi

et al. 2024

Azb Pharm Pharmaco J

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“…Nrf2 is a member of the cap'n'collar (CNC) basic-leucine-zipper transcription-factor, Nrf2 is considered as a master regulator of oxidative stress through enhance expression of anti-oxidant genes of glutathione and thioredoxin-antioxidant systems and also Aldo-keto reductase, and NAD (P) H quinine-oxide-reductase-1, HO-1, NQO-1, SODs, GPx, GSTs, GCL, CAT, TRX Nrf2 system has anti-inflammatory, anti-apoptotic, and anti-oxidant through different pathways (18,19). Nrf2 is a member of the CNC family which includes AP-1, NFE-2, Nrf-1, Nrf-2, Nrf-3, Bach-1 and -2, small-Mafs, and CREB/ATF and it can be divided into seven domains called Nrf2-ECH-homology (Neh) domains Neh-1 to Neh-7 (20) (Figure 2).…”

Section: Antiviral Activity Of Nrf2 Activatorsmentioning

confidence: 99%

The Nrf2 Activator (DMF) and Covid-19: Is there a Possible Role?

et al. 2020

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Introduction: COVID-19 is a new viral illness that can affect the lungs and airways with lethal consequences leading to the death of the patients. The ACE2 receptors were widely disturbed among body tissues such as lung, kidney, small intestine, heart, and others in different percent and considered a target for the nCOVID-19 virus. S-protein of the virus was binding to ACE2 receptors caused downregulation of endogenous anti-viral mediators, upregulation of NF-κB pathway, ROS and pro-apoptotic protein. Nrf2 was a transcription factor that's play a role in generation of anti-oxidant enzymes. Aim: To describe and establish role of Nrf2 activators for treatment COVID-19 positive patients. Methods: We used method of analysis of the published papers with described studies about COVID-19 connected with pharmacological issues and aspects which are included in global fighting against COVID-19 infection, and how using DMF (Nrf2 activator) in clinical trial for nCOVID-19 produce positive effects in patients for reduce lung alveolar cells damage. Results: we are found that Nrf2 activators an important medication that's have a role in reduce viral pathogenesis via inhibit virus entry through induce SPLI gene expression as well as inhibit TRMPSS2, upregulation of ACE2 that's make a competition with the virus on binding site, induce gene expression of anti-viral mediators such as RIG-1 and INFs, induce anti-oxidant enzymes, also they have a role in inhibit NF-κB pathway, inhibit both apoptosis proteins and gene expression of TLRs. Conclusion: We are concluded that use DMF (Nrf2 activator) in clinical trial for nCOVID-19 positive patients to reduce lung alveolar cells damage.

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“…Our findings suggest that infliximab and DMF have a protective effect against the ciprofloxacin induced-renal injury model by decreasing TNF-α, NF-κBp65, and IL-6 in renal tissue, as well as upregulating Bcl-2 in the pretreated groups compared with the ciprofloxacin group. This protective effect is likely due to the inhibition of a number of pro-apoptotic and inflammatory cytokines that were produced in response to kidney injury [ 17 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Group 1 was given 30 mg/kg of DMF 24 hours before the delivery of CIP, while Group 4 received an intraperitoneal injection of CIP. Group 5 received the same intraperitoneal injection of CIP as Group 1 and was administered infliximab plus DMF 24 hours beforehand [ 16 , 17 ]. All groups underwent intraperitoneal administration of ketamine hydrochloride at a dose of 50 mg/kg by Parke-Davis Eczacisi in Istanbul, Turkey.…”

Section: Methodsmentioning

confidence: 99%

The potential effect of infliximab, dimethyl fumarate (DMF), and their combination in ciprofloxacin-induced renal toxicity in male rats

Hassan¹,

Jawad²,

Rasool³

2023

JMedLife

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The aim of this study was to evaluate the effectiveness of infliximab and dimethyl fumarate (DMF) in reducing renal damage induced by ciprofloxacin. Forty rats were divided into five groups of eight each, with normal saline and CIP 600 mg IP administered to all animals in Groups 1 and 2 for ten days. Groups 3 and 4 were administered infliximab 7 mg/kg and DMF 30 mg/kg 24 hours before the CIP injections. Group 5 received a combination of infliximab/DMF after 24 hours of CIP. The levels of TNF-α, NF-Bp65, and IL-6 were measured, and the results showed that both infliximab and DMF had similar effects. However, the combination of infliximab and DMF had a robust anti-inflammatory and antiapoptotic impact, reducing TNF-α, NF-Bp65, IL-6, and Bcl-2 compared to the renal control group. Bcl-2 immuno-expression was lower in the ciprofloxacin group compared to the control group. DMF and infliximab had no effect on Bcl-2-positive cells, whereas infliximab increased the percentage of Bcl-2-positive cells substantially. CIP induced nephrotoxicity by increasing cytokine release and cell death signaling. Both infliximab and DMF are powerful TNF-α blockers that suppress cytokine release, preventing cell death and apoptosis caused by cytokines. Controlling inflammation and apoptosis can prevent nephrotoxicity.

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Bardoxolone Ameliorates Cerebral Ischemia/ Reperfusion Injury in Male Rats

Cited by 6 publications

References 31 publications

Resveratrol can Reduce the Aggressiveness of Hypoxic Colon Cancer Cells

Resveratrol can Reduce the Aggressiveness of Hypoxic Colon Cancer Cells

The Nrf2 Activator (DMF) and Covid-19: Is there a Possible Role?

The potential effect of infliximab, dimethyl fumarate (DMF), and their combination in ciprofloxacin-induced renal toxicity in male rats

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