“…Clinical Features 1, 7,8,19,22 Type 1 TGFβR1 Arterial aneurysms, aortic root dilation, early aortic dissection, and vascular tortuosity with facial dysmorphic features (hypertelorism, bifid uvula, cleft palate) Type 2 TGFβR2 Arterial aneurysms, aortic root dilation, early aortic dissection, and vascular tortuosity with cutaneous features (atrophic scarring, visible veins, poor wound healing) Type 3 SMAD3 Arterial aneurysms, aortic root dilation, and vascular tortuosity with bone and sometimes joint pathology (osteoarthritis, osteochondritis dessicans) Type 4…”