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Background Situs inversus is a congenital malformation that occurs in one or multiple organs simultaneously and can be accompanied by malformations in other body parts. We analyzed the prevalence and phenotype of patients with situs inversus and comorbidities associated with other plastic surgery–related malformations to enhance the knowledge of its related disorders and facilitate treatment. Methods We recruited patients with situs inversus who were seen at our institution from February 2015 to July 2023. They underwent ultrasound and physical examinations to investigate deformity in other body parts. Fisher's exact test was used to analyze the laterality between hemifacial microsomia and situs inversus type. Results All 14 patients with situs inversus had plastic surgery–related malformations—three congenital and three developmental. Nine (65%) patients had hemifacial microsomia (right side, n = 8; bilateral, n = 1). The laterality of hemifacial microsomia was associated with the situs inversus type, with a significant difference (P < 0.05), and hemifacial microsomia occurred ipsilaterally in patients with right-sided hearts. Conclusions Early situs inversus diagnosis is clinically important for patients and plastic surgeons. Further studies on anomalies associated with situs inversus will improve our understanding of their etiology.
Background Situs inversus is a congenital malformation that occurs in one or multiple organs simultaneously and can be accompanied by malformations in other body parts. We analyzed the prevalence and phenotype of patients with situs inversus and comorbidities associated with other plastic surgery–related malformations to enhance the knowledge of its related disorders and facilitate treatment. Methods We recruited patients with situs inversus who were seen at our institution from February 2015 to July 2023. They underwent ultrasound and physical examinations to investigate deformity in other body parts. Fisher's exact test was used to analyze the laterality between hemifacial microsomia and situs inversus type. Results All 14 patients with situs inversus had plastic surgery–related malformations—three congenital and three developmental. Nine (65%) patients had hemifacial microsomia (right side, n = 8; bilateral, n = 1). The laterality of hemifacial microsomia was associated with the situs inversus type, with a significant difference (P < 0.05), and hemifacial microsomia occurred ipsilaterally in patients with right-sided hearts. Conclusions Early situs inversus diagnosis is clinically important for patients and plastic surgeons. Further studies on anomalies associated with situs inversus will improve our understanding of their etiology.
Obesity has been recognized as a chronic disorder by the World Health Organisation (WHO) and was first reported in the Paleolithic age. In the recent years there has not been an international collaborative that facilitates professional cooperation on a worldwide level to increase the output of high-level evidence in the fields of obesity treatment and metabolic and bariatric surgery (MBS). In other surgical and medical fields, international collaborative research networks have shown to increase the quality and amount of treatment-changing evidence. In general, Global Collaborative Research in MBS (GCRMBS) should have the following goals: (1) clinical specialty–based research in obesity and MBS, (2) designing research protocols and studies to generate long-term data in obesity and MBS, (3) understanding the uncommon/rare complications and events associated with obesity and MBS, (4) increasing the number of participants in research and (5) investigating ethical and racial disparities in bariatric research. This review gives an overview of the current status and the future of international collaborative research in MBS.
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