Bariatric surgery and liver transplantation, here we are now: A French nationwide retrospective study

Dumortier, Jérôme; Erard, Domitille; Villeret, François; Faitot, François; Duvoux, Christophe; Faure, Stéphanie; Francoz, Claire; Gugenheim, Jean; Hardwigsen, Jean; Hiriart, Jean‐Baptiste; Houssel‐Debry, Pauline; Bello, Arnaud Del; Lassailly, Guillaume; Vanlemmens, Claire; Saliba, Faouzi; Altman, Claude; Latournerie, Marianne; Dharancy, Sébastien; Debs, Tarek

doi:10.1016/j.clinre.2023.102164

Clinics and Research in Hepatology and Gastroenterology

2023

DOI: 10.1016/j.clinre.2023.102164

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Bariatric surgery and liver transplantation, here we are now: A French nationwide retrospective study

Jérôme Dumortier

Domitille Erard

François Villeret

et al.

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2024

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Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) after Liver Transplantation: A Narrative Review of an Emerging Issue

Savino,

Loglio,

Neri

et al. 2024

JCM

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The development of steatotic liver disease after liver transplant (LT) is widely described, and epidemiological data have revealed an increased incidence in recent times. Its evolution runs from simple steatosis to steatohepatitis and, in a small proportion of patients, to significant fibrosis and cirrhosis. Apparently, post-LT steatotic disease has no impact on the recipient’s overall survival; however, a higher cardiovascular and malignancy burden has been reported. Many donors’ and recipients’ risk factors have been associated with this occurrence, although the recipient-related ones seem of greater impact. Particularly, pre- and post-LT metabolic alterations are strictly associated with steatotic graft disease, sharing common pathophysiologic mechanisms that converge on insulin resistance. Other relevant risk factors include genetic variants, sex, age, baseline liver diseases, and immunosuppressive drugs. Diagnostic evaluation relies on liver biopsy, although non-invasive methods are being increasingly used to detect and monitor both steatosis and fibrosis stages. Management requires a multifaceted approach focusing on lifestyle modifications, the optimization of immunosuppressive therapy, and the management of metabolic complications. This review aims to synthesize the current knowledge of post-LT steatotic liver disease, focusing on the recent definition of metabolic-dysfunction-associated steatotic liver disease (MASLD) and its metabolic and multisystemic concerns.

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Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) after Liver Transplantation: A Narrative Review of an Emerging Issue

Savino,

Loglio,

Neri

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

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Bariatric surgery and liver transplantation, here we are now: A French nationwide retrospective study

Cited by 1 publication

References 11 publications

Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) after Liver Transplantation: A Narrative Review of an Emerging Issue

Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) after Liver Transplantation: A Narrative Review of an Emerging Issue

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