Bariatric surgery for non-alcoholic steatohepatitis in obese patients

Non-alcoholic fatty liver disease resolution following sleeve gastrectomy

“…This finding is not the first in the field of bariatric surgery, as evident in the Cochrane review of 21 studies [22]. Within this review, 18 of these studies showed a significant improvement of NAFLD following bariatric surgery, showing that surgical intervention for obesity also reduces its associated comorbidities.…”

Total Body Weight Loss of ≥10 % Is Associated with Improved Hepatic Fibrosis in Patients with Nonalcoholic Steatohepatitis

“…It is unclear whether weight loss alone in bariatric surgery leads to fibrosis regression, as this has not been documented with medical weight loss, or whether it is another factor related to bariatric surgery, such as the improvement in glucose intolerance which occurs immediately after bariatric surgery. A recent Cochrane review concluded that the current literature is too limited for a definitive conclusion on the safety and efficacy of bariatric surgery as a primary therapy for NASH [17].…”

Influence of Liver Disease on Perioperative Outcome After Bariatric Surgery in a Northern German Cohort

“…While most authors describe a reduction in all features of NAFLD [28], others reported an increase of liver fibrosis in bariatric patients with unknown relevance [29]. A Cochrane meta-analysis could not show a specific impact of bariatric surgery on NASH due to insufficient studies [30]. More studies are needed to confirm expectations in treatment of NASH by bariatric surgery.…”