Bariatric surgery improves clinical outcomes and adiposity biomarkers but not inflammatory cytokines SAA and MCP-1 after a six-month follow-up

Bratti, Letícia de Oliveira Souza; Carmo, Ícaro Andrade Rodrigues do; Vilela, Taís Ferreira; Souza, Liliete Canes; Moraes, Ana Carolina Rabello de; Filippin-Monteiro, Fabíola Branco

doi:10.1080/00365513.2021.1904278

Cited by 7 publications

(2 citation statements)

References 51 publications

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“…The remission of CVD risk and other comorbidities of obesity is linked to the resolution of obesity-induced inflammation [10]. Levels of MCP-1 were reduced significantly after procedures at different postoperative periods [23,24] and showed insignificant changes in another study [25]. This ameliorative effect was also reported in levels of IL-6, TNF-α, and CRP [26].…”

Section: Discussionmentioning

confidence: 83%

Inflammatory Cytokines, Redox Status, and Cardiovascular Diseases Risk after Weight Loss via Bariatric Surgery and Lifestyle Intervention

et al. 2023

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Background and Objectives: Obesity is a chronic inflammatory condition and is considered a major risk factor for cardiovascular disease (CVD). The effects of obesity management via sleeve gastrectomy (SG) and lifestyle intervention (LS) on inflammatory cytokines, redox status, and CVD risk were studied in this work. Materials and Methods: A total of 92 participants (18 to 60 years old) with obesity (BMI ≥ 35 kg/m2 were divided into two groups: the bariatric surgery (BS) group (n = 30), and the LS group (n = 62). According to the achievement of 7% weight loss after 6 months, the participants were allocated to either the BS group, the weight loss (WL) group, or the weight resistance (WR) group. Assessments were performed for body composition (by bioelectric impedance), inflammatory markers (by ELISA kits), oxidative stress (OS), antioxidants (by spectrophotometry), and CVD risk (by the Framingham risk score (FRS) and lifetime atherosclerotic cardiovascular disease risk (ASCVD)). Measurements were taken before and after six months of either SG or LS (500 kcal deficit balanced diet, physical activity, and behavioral modification). Results: At the final assessment, only 18 participants in the BS group, 14 participants in the WL group, and 24 participants in the WR group remained. The loss in fat mass (FM) and weight loss were greatest in the BS group (p < 0.0001). Levels of IL-6, TNF-a, MCP-1, CRP, and OS indicators were significantly reduced in the BS and WL groups. The WR group had significant change only in MCP-1 and CRP. Significant reductions in the CVD risk in the WL and BS groups were detected only when using FRS rather than ASCVD. The FM loss correlated inversely with FRS-BMI and ASCVD in the BS group, whereas in the WL group, FM loss correlated only with ASCVD. Conclusions: BS produced superior weight and fat mass loss. However, both BS and LS produced a similar reduction in the inflammatory cytokines, relief of OS indicators, and enhancement of antioxidant capacity, and consequently reduced the CVD risk.

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Section: Discussionmentioning

confidence: 83%

Inflammatory Cytokines, Redox Status, and Cardiovascular Diseases Risk after Weight Loss via Bariatric Surgery and Lifestyle Intervention

et al. 2023

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“…To the best of our knowledge, there is no reliable biomarker that predicts successful TWL and/or WR after BS. Overall, BS restores metabolic homeostasis [ 32 ]; apart from TWL and reduction in waist circumference (WC), there is an increase in SHBG levels on the first month after BS, accompanied by the secretion of anti-inflammatory and insulin-sensitizing factors [ 33 – 35 ]. On these bases, we designed the present study to explore the impact of BS on SHBG, as well as the potential role of SHBG as reliable biomarker for predicting TWL and WR after BS in patients with obesity.…”

Section: Introductionmentioning

confidence: 99%

Plasma SHBG Levels as an Early Predictor of Response to Bariatric Surgery

Gabriel-Medina,

Ferrer-Costa,

Rodriguez-Frias

et al. 2024

OBES SURG

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Background Obesity is a growing global health problem, and currently, bariatric surgery (BS) is the best solution in terms of sustained total weight loss (TWL). However, a significant number of patients present weight regain (WR) in time. There is a lack of biomarkers predicting the response to BS and WR during the follow-up. Plasma SHBG levels, which are low in obesity, increase 1 month after BS but there is no data of plasma SHBG levels at long term. We performed the present study aimed at exploring the SHBG role in predicting TWL and WR after BS. Methods Prospective study including 62 patients with obesity undergoing BS. Anthropometric and biochemical variables, including SHBG were analyzed at baseline, 1, 6, 12, and 24 months; TWL ≥ 25% was considered as good BS response. Results Weight loss nadir was achieved at 12 months post-BS where maximum SHBG increase was reached. Greater than or equal to 25% TWL patients presented significantly higher SHBG increases at the first and sixth months of follow-up with respect to baseline (100% and 150% respectively, p = 0.025), than < 25% TWL patients (40% and 50% respectively, p = 0.03). Also, these presented 6.6% WR after 24 months. The first month SHBG increase predicted BS response at 24 months (OR = 2.71; 95%CI = [1.11–6.60]; p = 0.028) and TWL in the 12th month (r = 0.330, p = 0.012) and the WR in the 24th (r = − 0.301, p = 0.028). Conclusions Our results showed for the first time that increase in plasma SHBG levels within the first month after BS is a good predictor of TWL and WR response after 2 years. Graphical Abstract

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Effect of Bariatric Surgery on Serum Amyloid A Protein: a Systematic Review and Meta-analysis

Jamialahamdi,

Mirhadi,

Atkin

et al. 2023

OBES SURG

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Bariatric surgery improves clinical outcomes and adiposity biomarkers but not inflammatory cytokines SAA and MCP-1 after a six-month follow-up

Cited by 7 publications

References 51 publications

Inflammatory Cytokines, Redox Status, and Cardiovascular Diseases Risk after Weight Loss via Bariatric Surgery and Lifestyle Intervention

Inflammatory Cytokines, Redox Status, and Cardiovascular Diseases Risk after Weight Loss via Bariatric Surgery and Lifestyle Intervention

Plasma SHBG Levels as an Early Predictor of Response to Bariatric Surgery

Effect of Bariatric Surgery on Serum Amyloid A Protein: a Systematic Review and Meta-analysis

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