Bariatric surgery-induced weight loss reduces B cell activating cytokines and IgG immunoglobulins related to autoimmunity

Cuellar-Tamez, R X; Villarreal-Calderón, José R; Rubio-Infante, Néstor; Castillo, Elena C.; García-Garza, Manuel; Elizondo‐Montemayor, Leticia; García‐Rivas, Gerardo

doi:10.1007/s00464-020-08004-6

Cited by 10 publications

(8 citation statements)

References 48 publications

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“…At baseline, higher levels of all three cytokines compared with HD were observed. These findings are consistent with previous reports on pwMS as well as reports on several autoimmune and inflammatory states [ 16 , 17 , 18 , 19 , 20 , 52 , 53 , 54 ]. Specifically, DMTs reportedly influence plasma BAFF levels in pwMS, but the significance of these changes remains unclear.…”

Section: Discussionsupporting

confidence: 94%

Evaluation of BAFF, APRIL and CD40L in Ocrelizumab-Treated pwMS and Infectious Risk

Zingaropoli

Pasculli

Tartaglia

et al. 2023

Biology

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Background: The anti-CD20 monoclonal antibody ocrelizumab has been widely employed in the treatment of people with multiple sclerosis (pwMS). However, its B-cell-depleting effect may induce a higher risk of infectious events and alterations in the secretion of B-cell-activating factors, such as BAFF, APRIL and CD40L. Methods: The aim of this study was to investigate plasma BAFF, APRIL and CD40L levels and their relationship with infectious risk in ocrelizumab-treated pwMS at baseline (T0), at 6 months (T6) and at 12 months (T12) after starting the treatment. As a control group, healthy donors (HD) were enrolled too. Results: A total of 38 pwMS and 26 HD were enrolled. At baseline, pwMS showed higher plasma BAFF (p < 0.0001), APRIL (p = 0.0223) and CD40L (p < 0.0001) levels compared to HD. Compared to T0, plasma BAFF levels were significantly increased at both T6 and T12 (p < 0.0001 and p < 0.0001, respectively). Whereas plasma APRIL and CD40L levels were decreased at T12 (p = 0.0003 and p < 0.0001, respectively). When stratifying pwMS according to the development of an infectious event during the 12-month follow-up period in two groups—with (14) and without an infectious event (24)—higher plasma BAFF levels were observed at all time-points; significantly, in the group with an infectious event compared to the group without an infectious event (T0: p < 0.0001, T6: p = 0.0056 and T12: p = 0.0400). Conclusions: BAFF may have a role as a marker of immune dysfunction and of infectious risk.

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Section: Discussionsupporting

confidence: 94%

Evaluation of BAFF, APRIL and CD40L in Ocrelizumab-Treated pwMS and Infectious Risk

Zingaropoli

Pasculli

Tartaglia

et al. 2023

Biology

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“…Only a few studies have reported decreased IgG levels in plasma after RYGB surgery. A study reported that total IgG antibody decreased 6 months after RYGB surgery [43], in line with our finding. Another study reported a decrease in IgG, 5 and 10 months after RYGB [44].…”

Section: Discussionsupporting

confidence: 93%

Impact of RYGB surgery on plasma immunoglobulins: association between blood pressure and glucose levels six months after surgery

Happonen,

Härma,

Akhi

et al. 2023

APMIS

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We aimed to study levels of natural antibodies in plasma, and their associations to clinical and fecal biomarkers, before and 6 months after Roux‐en‐Y gastric bypass (RYGB) surgery. Thirty individuals with obesity [16 type 2 diabetic, 14 non‐diabetic (ND)] had RYGB surgery. Total plasma IgA, IgG and IgM antibody levels and specific antibodies to oxidized low‐density lipoprotein (oxLDL), malondialdehyde‐acetaldehyde adducts, Porphyromonas gingivalis gingipain A hemagglutinin domain (Rgp44), and phosphocholine were measured using chemiluminescence immunoassay. Associations between plasma and fecal antibodies as well as clinical markers were analyzed. RYGB surgery reduced blood pressure, and the glycemic state was improved. A higher level of diastolic blood pressure was associated with lower plasma antibodies to oxLDL after surgery. Also, lower level of glucose markers associated with lower level of plasma antibodies to bacterial virulence factors. Antibodies to oxLDL decreased after surgery, and positive association between active serum lipopolysaccharide and specific oxLDL antibodies was detected. Total IgG levels decreased after surgery, but only in ND individuals. Reduced level of total plasma IgG, improved state of hypertension and hyperglycemia and their associations with decreased levels of specific antibodies in plasma, suggest an improved state of systemic inflammation after RYGB surgery.

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“…B-cell activating factors, including APRIL, BAFF, and soluble CD40L, as well as systematic inflammatory factors, including high sensitivity CRP, IL-1β, IL-12, IL-18, and IFN- γ , decrease after bariatric surgery. These changes may lead to a decrease in B-cell activity, IgG levels, and systemic inflammation ( 39 ). Meanwhile, a reduction in CD4+ and CD8+ T cell counts and a decrease in the Th1/Th2 ratio were also identified after bariatric surgery ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy

Chi

Wu²,

Chen³

et al. 2022

Front. Surg.

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PurposeThis study aims to identify the pre- and postoperative changes in the neutrophil-lymphocyte ratio (NLR) and its correlations to clinical characteristics in obese patients who underwent laparoscopic sleeve gastrectomy (LSG).MethodRetrospectively, we included patients who has undergone LSG in our institution between January 2019 and April 2021. A total of 100 patients whose body mass index over 32.5 and received primary laparoscopic sleeve gastrectomy without infectious condition were included.ResultsThere was a significant decline in NLR (T0 vs. POM3 2.21 vs. 1.78, p = 0.005), neutrophil (T0 vs. POM3 5369 vs. 4050, p < 0.001) and lymphocyte count (T0 vs. POM3 2440: 2100, p < 0.001, respectively) at postoperative 3 months (POM3) compared to preoperative (T0) levels, but similar between POM3 and POM6. The declined counts (Neutrophile vs. Lymphocyte 1445.5/µl vs. 323.5/µl, p < 0.001) and percentage (Neutrophile vs. Lymphocyte 25.11% vs. 13.07%, p < 0.001) of neutrophile are higher than lymphocyte from T0 to POM3, but similar in POM3 and POM6. Preoperative NLR has a significant correlation with the preoperative body weight, preoperative insulin level, and excessive body weight loss (EBWL) at POM3. Preoperative NLR <2.36 had a sensitivity of 67.6% and a specificity of 62.5% in predicting successful weight loss (EBWL > 37.7%) at POM3 (AUC = 0.635, p = 0.032).ConclusionThere was a significant decline in NLR, neutrophil, and lymphocyte count from T0 to POM3, but similar between POM3 and POM6. The declined counts and percentage of neutrophile are higher than lymphocyte. Preoperative NLR shows the potential to be used as a prognostic biomarker for predicting successful weight loss at POM3 after LSG. Further studies could be designed to evaluate the value of prediction in successful outcome after LSG and figure out the relationship between the changes of neutrophil function and oncogenesis.

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Bariatric surgery-induced weight loss reduces B cell activating cytokines and IgG immunoglobulins related to autoimmunity

Cited by 10 publications

References 48 publications

Evaluation of BAFF, APRIL and CD40L in Ocrelizumab-Treated pwMS and Infectious Risk

Evaluation of BAFF, APRIL and CD40L in Ocrelizumab-Treated pwMS and Infectious Risk

Impact of RYGB surgery on plasma immunoglobulins: association between blood pressure and glucose levels six months after surgery

The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy

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