Bariatric Surgery Is Associated with a Reduction in Major Macrovascular and Microvascular Complications in Moderately to Severely Obese Patients with Type 2 Diabetes Mellitus

Johnson, Brent L.; Blackhurst, Dawn W.; Latham, Bruce B.; Cull, David L.; Bour, Eric S.; Oliver, Thomas L.; Williams, Bradley R.; Taylor, Spence M.; Scott, John D.

doi:10.1016/j.jamcollsurg.2012.12.019

Cited by 127 publications

(134 citation statements)

References 65 publications

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“…The concomitant resolution of lethal comorbidities, including hypertension, dyslipidaemia, type 2 diabetes mellitus, and NAFLD, and indirectly lowering the risk of myocardial infarction and transient ischemic attacks are a few examples [16][17][18]. In this study, the question was posed in regard to a possible correlation of sleeve gastrectomy and the resolution of NAFLD, a serious disease with fatal consequences.…”

Section: Discussionmentioning

confidence: 99%

Non-alcoholic fatty liver disease resolution following sleeve gastrectomy

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Non-alcoholic fatty liver disease resolution following sleeve gastrectomy

et al. 2015

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“…Jose et al [40] examined renal function at 4-year follow-up post-BPD in 25 patients with class III obesity including five patients with diabetes. Serum creatinine reduced by 16.2±19.6 μmol/L, and estimated glomerular filtration rate (eGFR) increased by 10.6±15.5 mL/min/m 2 in the context of a mean weight loss of 30 %.In larger retrospective series, Johnson et al[41] examined microvascular outcomes in 2580 patients undergoing bariatric surgery and 13,371 non-operated controls meeting the same inclusion criteria. Surgery was associated with a significant reduction in microvascular events including end-…”

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confidence: 99%

Weight Loss Interventions and Progression of Diabetic Kidney Disease

2015

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Progressive renal impairment (diabetic kidney disease (DKD)) occurs in upwards of 40 % of patients with obesity and type 2 diabetes mellitus (T2DM) and is a cause of significant morbidity and mortality. Means of attenuating the progression of DKD focus on amelioration of risk factors. Visceral obesity is implicated as a causative agent in impaired metabolic and cardiovascular control in T2DM, and various approaches primarily targeting weight have been examined for their impact on markers of renal injury and dysfunction in DKD. The current report summarises the evidence base for the impact of surgical, lifestyle and pharmacological approaches to weight loss on renal end points in DKD. The potential for a threshold of weight loss more readily achievable by surgical intervention to be a prerequisite for renal improvement is highlighted. Comparing efficacious non-surgical weight loss strategies with surgical strategies in appropriately powered and controlled prospective studies is a priority for the field.

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“…29,30 In this report, we showed that metabolic surgery is a promising and [31][32][33][34][35] Successful remission of T2DM in this group of patients can be translated to a decrease of diabetes-related mortality. 8,36,37 Recent studies disclosed that bariatric surgery can reduce mortality by up to 30-40 % and, more importantly, that the reduction of mortality by bariatric surgery was mostly attributed to the reduction of diabetes-related death. 8,38 These data constitute a good argument for proposing metabolic surgery in inadequately controlled obesity-related T2DM patients as soon as possible.…”

Section: Discussionmentioning

confidence: 99%