Barium titanate core – gold shell nanoparticles for hyperthermia treatments

Abstract

Abstract:The development of new tools and devices to aid in treating cancer is a hot topic in biomedical research. The practice of using heat (hyperthermia) to treat cancerous lesions has a long history dating back to ancient Greece. With deeper knowledge of the factors that cause cancer and the transmissive window of cells and tissues in the near-infrared region of the electromagnetic spectrum, hyperthermia applications have been able to incorporate the use of lasers. Photothermal therapy has been introduced as a selective and noninvasive treatment for cancer, in which exogenous photothermal agents are exploited to achieve the selective destruction of cancer cells. In this manuscript, we propose applications of barium titanate core-gold shell nanoparticles for hyperthermia treatment against cancer cells. We explored the effect of increasing concentrations of these nanoshells (0-100 µg/mL) on human neuroblastoma SH-SY5Y cells, testing the internalization and intrinsic toxicity and validating the hyperthermic functionality of the particles through near infrared (NIR) laser-induced thermoablation experiments. No significant changes were observed in cell viability up to nanoparticle concentrations of 50 µg/mL. Experiments upon stimulation with an NIR laser revealed the ability of the nanoshells to destroy human neuroblastoma cells. On the basis of these findings, barium titanate core-gold shell nanoparticles resulted in being suitable for hyperthermia treatment, and our results represent a promising first step for subsequent investigations on their applicability in clinical practice.

Piezoelectric Effects of Materials on Bio-Interfaces

“…Finally, future works will be dedicated to further explore the potential in nanomedicine of other piezoelectric nanostructures, such as the multiferroic ones composed by bismuth ferrite (BFO) and metal-based hybrid nanomaterials (e.g., piezoelectric gold-based nanocomposites) . As an example, gold nanoshells with a piezoelectric BTNP core have already demonstrated first good results in the field of photothermal ablation therapy of cancer cells …”

“…92 As an example, gold nanoshells with a piezoelectric BTNP core have already demonstrated first good results in the field of photothermal ablation therapy of cancer cells. 93…”

Gold-seeded Lithium Niobate Nanoparticles: Influence of Gold Surface Coverage on Second Harmonic Properties

“…Coupling efficient nonlinear optical NPs with gold nanostructures was investigated by several research groups during the last few years, both with NPs deposited on substrates such as nanoantennas [ 16 , 17 ] or on core-shell NPs dispersed in a liquid [ 18 , 19 , 20 , 21 , 22 ]. Concerning core-shell NPs and nanowires, an enhancement of SHG intensities was observed for potassium niobate nanowires coated with a gold shell, at fundamental excitation wavelengths matching the localized surface plasmon resonance of the gold-covered nanowire between 900 and 1000 nm [ 20 ].…”

Comparison of Four Common Gold Nanoparticles for Photothermal Cancer Therapy: A Review

“…Hyperthermia is a non-invasive cancer therapy where malignant cells are exposed to localized heat greater than 43 °C [17,18,19]. Conventional hyperthermia can cause damage to surrounding tissues, burns, pain at the target site, blood clots, infection, and swelling [20,21].…”