Barker Hypothesis and Hypertension

Jebasingh, Felix; Nicolaï, Thomas

doi:10.3389/fpubh.2021.767545

Cited by 19 publications

(8 citation statements)

References 44 publications

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“…Consistent with this, we observed similar results in our previous and current study [ 12 , 23 ], as both the absolute and relative weight of the liver were significantly lower in IUGR piglets. Combined with our previous report, IUGR piglets undergo rapid catch-up growth in the early postnatal period; this may be due to the malnourished liver adapting to the abundant postnatal environment, and gaining excessive growth relative to other organs, which may in turn be detrimental to hepatic function, further exacerbating risk of metabolic syndrome [ 24 ].…”

Section: Discussionmentioning

confidence: 89%

Integrative Analysis of Liver Metabolomics and Transcriptomics Reveals Oxidative Stress in Piglets with Intrauterine Growth Restriction

Gao

Chen

Zhao

et al. 2022

Biology

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The correlation between oxidative stress and liver metabolic dysfunction in piglets with intrauterine growth restriction (IUGR) remains limited. Therefore, the objective of the present study was to investigate potential mechanisms of metabolic characteristics induced by oxidative stress in the livers of IUGR piglets using metabolomic and transcriptomic analysis. Analysis of the phenotypic characteristics showed that the liver weight of the intrauterine growth restriction piglets was significantly lower than that of normal birth weight piglets. Intrauterine growth restriction piglets exhibited disordered hepatic cord arrangement and vacuolization as well as excessive lipid accumulation in hepatocytes. In addition, the activities of antioxidant enzymes were significantly decreased in the liver of the intrauterine growth restriction piglets, whereas the level of the lipid peroxidation marker MDA was significantly increased. Finally, our findings revealed that intrauterine growth restriction piglets were involved in a variety of metabolic abnormalities, including mitochondrial dysfunction, imbalance of fatty acid composition, disruption to sources of one-carbon unit supply, and abnormal galactose conversion, which may be responsible for oxidative stress in the liver. In summary, these data provided a detailed theoretical reference for revealing the hepatic metabolic characteristics of intrauterine growth restriction piglets.

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Section: Discussionmentioning

confidence: 89%

Integrative Analysis of Liver Metabolomics and Transcriptomics Reveals Oxidative Stress in Piglets with Intrauterine Growth Restriction

Gao

Chen

Zhao

et al. 2022

Biology

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“…Nephron mass at birth may be determined by low birth weight and this may reflect the nutritional status of the mother or other environmental stressors and may be relevant to subsequent development of CKD. 27 This may explain some of the differences between Nationalities. Unfortunately, a UAE biopsy registry no longer exists and anyway many of the identified patients with advanced CKD, especially some of the expatriates, present at a very late stage and with small kidneys and so do not get a biopsy.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gender, age and nationality differences in chronic kidney disease prevalence in the emirate of Abu Dhabi, UAE

Almadani,

Ahmed,

Al Obaidli

et al. 2024

Nephrology

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AimWe aimed to better understand the prevalence of chronic kidney disease in Abu Dhabi, UAE, where a very diverse ethnic population lives, each with their own risk profile.MethodsData were analysed on all patients who were tested for serum creatinine in December 2019 for 4 years within our healthcare network. We analysed data for kidney disease by age, gender and nationality to study differences in prevalence and risk.ResultsThe entire cohort (EC) consisted 1 925 672 samples from 703 122 patients. 24% of patients had GFR < 90 mL/min/1.73 m2 (CKD2‐5), 4% had more severe kidney dysfunction (CKD3‐5) and 2% had UACR >3 mg/mmol and with GFR > 90 (CKD1).The long follow‐up (LFU) group comprised 45.6% of patients who had eGFR on at least two occasions more than 90 days apart, and of these 19.5% had sustained eGFR <90, and 5.2% had CKD3‐5.Males had lower eGFR than females in the EC (RR 1.68) and the LFU group (RR 1.76). Emirati Females had the lowest prevalence in the EC (2.9%) and expatriate females in the LFU (3.5%) groups. The relative risks of CKD in expatriate males were highest in the EC (2.14) and the LFU (2.39) groups.When we looked at the age distribution by nationality there were highly significant differences in some populations being highly represented at younger ages.ConclusionThe prevalence of kidney disease in Abu Dhabi has a male predominance, with younger expatriates highly represented. A targeted strategy to identify those at high risk may identify early CKD to prevent progression to end‐stage kidney disease.image

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“…Substantial evidence in animal models and some in humans indicates that a part of disease risk inheritance is conferred nongenomically (not related to nucleotide identity) during development, with implications for transmission beyond one generation [28][29][30][31]. The developmental origins of health and disease (DOHaD) hypothesis advances the conceptual role of the prenatal environment in conferring risk of chronic and noncommunicable diseases across the lifespan, including HTN, type 2 diabetes and other metabolic syndrome phenotypes, obesity, cardiovascular disease, and neuropsychiatric disorders [28,[32][33][34][35]. The placenta, a dynamic organ at the maternal-fetal boundary, is the site of adaptation to both fetal and maternal needs during gestation and pregnancy.…”

mentioning

confidence: 99%

Association of genetically-predicted placental gene expression with adult blood pressure traits

Hellwege¹,

Stallings²,

Piekos

et al. 2023

Journal of Hypertension

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Objective:Blood pressure is a complex, polygenic trait, and the need to identify prehypertensive risks and new gene targets for blood pressure control therapies or prevention continues. We hypothesize a developmental origins model of blood pressure traits through the life course where the placenta is a conduit mediating genomic and nongenomic transmission of disease risk. Genetic control of placental gene expression has recently been described through expression quantitative trait loci (eQTL) studies which have identified associations with childhood phenotypes.Methods:We conducted a transcriptome-wide gene expression analysis estimating the predicted gene expression of placental tissue in adult individuals with genome-wide association study (GWAS) blood pressure summary statistics. We constructed predicted expression models of 15 154 genes from reference placenta eQTL data and investigated whether genetically-predicted gene expression in placental tissue is associated with blood pressure traits using published GWAS summary statistics. Functional annotation of significant genes was generated using FUMA.Results:We identified 18, 9, and 21 genes where predicted expression in placenta was significantly associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP), respectively. There were 14 gene-tissue associations (13 unique genes) significant only in placenta.Conclusions:In this meta-analysis using S-PrediXcan and GWAS summary statistics, the predicted expression in placenta of 48 genes was statistically significantly associated with blood pressure traits. Notable findings included the association of FGFR1 expression with increased SBP and PP. This evidence of gene expression variation in placenta preceding the onset of adult blood pressure phenotypes is an example of extreme preclinical biological changes which may benefit from intervention.

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Barker Hypothesis and Hypertension

Cited by 19 publications

References 44 publications

Integrative Analysis of Liver Metabolomics and Transcriptomics Reveals Oxidative Stress in Piglets with Intrauterine Growth Restriction

Integrative Analysis of Liver Metabolomics and Transcriptomics Reveals Oxidative Stress in Piglets with Intrauterine Growth Restriction

Gender, age and nationality differences in chronic kidney disease prevalence in the emirate of Abu Dhabi, UAE

Association of genetically-predicted placental gene expression with adult blood pressure traits

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